Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 AlteredExpression disease BEFREE In this experimental study, human SSCs were isolated and their identities were confirmed by tracking their promyelocytic leukemia zinc finger (PLZF) protein. 30123997 2019
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 GeneticVariation disease BEFREE With RT-PCR and karyotype, Case A is diagnosed with STAT5b-RARα-positive APL.Case B, C are diagnosed with PLZF-RARα-positive APL. 31083206 2019
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE Herein, we for the first time report that phenylarsine oxide (PAO) could effectively induce PLZF-RARα variant fusion protein degradation through ubiquitin proteasome degradation pathway by apoptosis, which indicates that PAO might be a potential candidate for the treatment of PLZF-RARα variant APL. 30869512 2019
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 AlteredExpression disease BEFREE In addition, under steady-state conditions, DP T cells expressed eomesodermin (Eomes) and promyelocytic leukemia zinc finger (PLZF) proteins, both of which act as transcription factors in innate/memory-like T cells. 30116750 2018
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE CDC: Centers for Disease Control; DMSO: dimethyl sulfoxide; GHR: growth hormone receptor; hESCs: human embryonic stem cells; PFASs: per- and polyfluoroalkyl substances; PFCs: perfluorinated compounds; PFNA: perfluorononanoic acid; PFOS: perfluorooctanesulfonic acid; PFOA: perfluorooctanoic acid; PLZF: promyelocytic leukemia zinc finger; ROS: reactive oxygen species; HILI: RNA-mediated gene silencing 2; SSC: spermatogonial stem cell. 29911897 2018
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE Therefore, EYA2 may be a target for molecular therapy in this subtype of AML, including <i>PLZF-RARA</i> APL. 28416638 2017
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 GeneticVariation disease BEFREE Moreover, patients with APL carrying the PLZF-RARα fusion protein are partially resistant to ATRA treatment. 25931453 2015
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 AlteredExpression disease BEFREE The transcriptions of the proapoptotic genes, insulin-like growth factor binding protein 3 (IGFBP3) and BCL2-interacting killer (BIK), were suppressed by ZNF179 via its interaction with the promyelocytic leukemia zinc finger (PLZF) protein in astrocytes. 24788683 2015
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE The variant t(11;17) translocation produces two fusion proteins, promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα) and RARα-PLZF, both of which participate in leukemia development. 23898169 2013
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE By using a murine leukemic model carrying both promyelocytic leukemia zinc finger/retinoic acid receptor-α (PLZF/RARα) and RARα/PLZF fusion genes, we discovered that 8-chlorophenylthio adenosine-3', 5'-cyclic monophosphate (8-CPT-cAMP) enhances cellular differentiation and improves gene trans-activation by ATRA in leukemic blasts. 23382200 2013
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease CTD_human Acute promyelocytic leukemia (APL) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (RARA) gene and the promyelocytic leukemia (PML) or promyelocytic leukemia zinc finger (PLZF) gene. 23208507 2013
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 GeneticVariation disease BEFREE Acute promyelocytic leukemia (APL) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (RARA) gene and the promyelocytic leukemia (PML) or promyelocytic leukemia zinc finger (PLZF) gene. 23208507 2013
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE This paper describes two cases of APL associated with the PLZF-RARA fusion gene enrolled in the IC-APL trial that is a non-randomized, multicenter study conducted in Brazil, Mexico, Chile and Uruguay with the aim to improve the treatment outcome of APL patients in developing countries. 22205181 2012
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 GeneticVariation disease BEFREE The PLZF/RARA fusion protein generated by the t(11;17)(q23;q21) translocation in acute promyelocytic leukaemia (APL) is believed to act as an oncogenic transcriptional regulator recruiting epigenetic factors to genes important for its transforming potential. 21949697 2011
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 AlteredExpression disease BEFREE The promyelocytic leukemia zinc finger (PLZF) protein exerts neuroprotective effects in neuronal cells and is dysregulated in experimental stroke. 20731660 2011
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 GeneticVariation disease BEFREE The t(11;17)(q23;q21) translocation is associated with a retinoic acid (RA)-insensitive form of acute promyelocytic leukemia (APL), involving the production of reciprocal fusion proteins, promyelocytic leukemia zinc finger-retinoic acid receptor alpha (PLZF-RARalpha) and RARalpha-PLZF. 19855079 2009
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE The PLZF gene is one of five partners fused to the retinoic acid receptor alpha in acute promyelocytic leukaemia. 18611983 2008
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE Retinoic acid treatment of mouse APLs expressing the fusion protein PLZF-RARA triggers full differentiation, but not LIC loss or disease remission, establishing that differentiation and LIC loss can be uncoupled. 19029980 2008
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 AlteredExpression disease BEFREE In line with these observations, RA-resistant murine PLZF/RARalpha+RARalpha/PLZF APL blasts express much higher levels of CRABPI than standard RA-sensitive PML/RARalpha APL. 18000064 2007
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE The PLZF gene is one of five partners fused to the retinoic acid receptor alpha in acute promyelocytic leukemia. 17217037 2007
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 AlteredExpression disease BEFREE To determine whether the promyelocytic leukemia zinc finger (PLZF) protein, a transcriptional repressor and negative regulator during cell cycling, plays a role in the proliferation of cultured human corneal endothelial cells (HCECs). 17515885 2007
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 GeneticVariation disease BEFREE Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response. 17194664 2006
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 Biomarker disease BEFREE Combination chemotherapy can achieve sustained remission in patients with PLZF/RARalpha APML. 15592671 2005
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 AlteredExpression disease BEFREE As an approach to silencing estrogen-regulated genes, we have studied the activities of a fusion protein between ERalpha and the promyelocytic leukemia zinc-finger (PLZF) protein, a transcriptional repressor that acts through chromatin remodeling. 15647773 2005
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.600 GeneticVariation disease BEFREE This phenotype is induced by specific acute myeloid leukemia-associated translocations, such as t(15;17) and t(11;17), which involve an identical portion of the retinoic acid receptor alpha (RARalpha) and either the promyelocytic leukemia (PML) or promyelocytic zinc finger (PLZF) genes, respectively. 16024608 2005