Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.050 | Biomarker | disease | BEFREE | IRF4 may represent a therapeutic target in ATL because ATL cells select for a mutant of IRF4 with higher nuclear expression and transcriptional activity, and overexpression of IRF4 induces the expansion of T lymphocytes <i>in vivo</i>. | 29540473 | 2018 | ||||
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0.050 | AlteredExpression | disease | LHGDN | Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells. | 12218129 | 2002 | ||||
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0.050 | AlteredExpression | disease | BEFREE | We have examined the specific mechanisms underlying the expression and regulation of the IRF-4 transcription factor in HTLV-I-infected cells and have shown that constitutive IRF-4 expression is exclusive to the transformed, leukemic ATL phenotype as opposed to the nonleukemic HTLV-I associated myelopathies/tropical spastic paraparesis (HAM/TSP) phenotype. | 11846984 | 2002 | ||||
|
0.050 | AlteredExpression | disease | LHGDN | In vivo and in vitro analyses have identified several regulatory regions within the human IRF-4 promoter that interact with the transcriptional regulators NF-kappaB, NF-AT, and Sp-1 to drive IRF-4 production in HTLV-I-infected, ATL-derived cells. cDNA array analysis of an IRF-4-expressing T cell line has also provided valuable insight into potential IRF-4 target genes. | 11846984 | 2002 | ||||
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0.050 | GeneticVariation | disease | BEFREE | All HTLV-1 infected cell lines and ATL patient lymphocytes demonstrated a dramatic decrease in cyclin B1 levels; subsequent analysis of the cyclin B1 promoter identified two sites important in IRF-4 binding and repression of cyclin B1 expression. | 12360402 | 2002 | ||||
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0.050 | Biomarker | disease | BEFREE | Taken together, our results indicate that IRF4 is involved in the pathogenesis of ATL through its positive effect on the cell cycle, and that IRF4 can be used as a molecular marker of clinical subtype in ATL. | 11749693 | 2001 |