Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.350 Biomarker disease BEFREE Transcriptomic analysis and cell type deconvolution confirmed the <i>FAS</i> genotype/T<sub>SCM</sub> link and IFN-α-induced downregulation of CD4 T<sub>SCM</sub>-specific genes in ATL patient cells. 29721391 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.350 Biomarker disease BEFREE Type I interferons (IFNs) are key effectors of the innate antiviral response, and IFN-α combined with the nucleoside reverse transcriptase inhibitor zidovudine is considered the standard first-line therapy for ATL. 26819312 2016
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.350 Biomarker disease BEFREE Overall, our findings suggest that both HBZ and Tax1 are negative regulators of immediate early IFN-β innate immune responses, while HBZ but not Tax1 positively regulates the induction of IFN-α and downstream IFN-α signaling.<b>IMPORTANCE</b> Type I interferons are powerful antiviral cytokines and are used extensively in the treatment of HTLV-1-induced adult T cell leukemia (ATL). 28768861 2017
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.350 GeneticVariation disease BEFREE In this study, we demonstrate that an As(2)O(3) and IFN-α combination, known to trigger Tax proteolysis, cures Tax-driven ATL in mice. 21135137 2010
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.350 AlteredExpression disease BEFREE Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells. 12218129 2002
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.350 Therapeutic disease CTD_human Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha. 20370541 2010