Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE T-LGLL and ATL share dependence on IL-2 and IL-15 for survival and both diseases lack effective therapies. 30353031 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE BAY 1143572-treated ATL-bearing mice (once daily 12.5 mg/kg oral application) demonstrated significantly decreased ATL cell infiltration of the liver and bone marrow, as well as decreased human soluble interleukin-2 receptor levels in serum (reflecting the ATL tumor burden), compared with untreated mice (n = 8 for both). 28646117 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE In this study, by using IL-2-dependent HTLV-1-infected T-cell lines (ILTs) established from patients with ATL and HAM/TSP, we demonstrate that the anti-inflammatory cytokine IL-10 and its downstream signals potentially act as a switch for proliferation in HTLV-1-infected cells. 28910419 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 GeneticVariation disease BEFREE Transforming activity was further demonstrated by the ability of the FBXW7 D510E mutant to provide IL-2-independent growth of Tax-immortalized human T cells and increase the tumor formation in a xenograft mouse model of ATL. 27247421 2016
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia. 26396258 2015
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax. 25175936 2014
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease CTD_human "The combination of arsenic, interferon-alpha, and zidovudine restores an ""immunocompetent-like"" cytokine expression profile in patients with adult T-cell leukemia lymphoma." 23962110 2013
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth. 22010857 2012
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE These signaling proteins represent novel and promising molecular therapeutic targets for IL-2-dependent ATL. 22402124 2012
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 AlteredExpression disease BEFREE Abnormal IL-2Rα chain expression and the IL-2 dependency of ATL cell lines greatly contributed to the study of leukemogenesis of ATL. 22068231 2011
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE This suggests the existence of compensatory mechanisms in IL-2-dependent cells and ATLL patients. 18511807 2008
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE In this study, we demonstrated that withdrawal of interleukin (IL)-2 from IL-2-dependent ATL cell lines resulted in induction of HTLV-1 mRNA and protein expression, and that viral induction was associated with phosphorylation of the stress kinase p38 and its downstream CREB. 17950728 2007
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 AlteredExpression disease BEFREE HTLV-I transformed T-cell lines and fresh ATL cells are characterized by constitutive activation of the interleukin-2 receptor (IL-2R) signaling pathway however, the mechanism(s) responsible for constitutive IL-2R activation are unknown. 14630083 2004
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells. 11992406 2002
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE We previously demonstrated that interleukin 2 (IL-2) autocrine/paracrine growth in adult T-cell leukaemia (ATL) cells was closely correlated with clinical aggressiveness. 12406087 2002
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE Here, we report that IL-2-dependent ATL cell lines also express IL-4Ralpha and respond to IL-4, which was verified by the activation of cytoplasmic transcriptional activator Stat6 protein. 12225394 2002
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE Recently, novel treatments, such as monoclonal antibodies directed at the interleukin-2 receptor and the combination of interferon alfa and zidovudine, have been shown to be active in the treatment of patients with ATL. 12057109 2001
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE These findings indicate that Gfi-1 activation is involved in the IL-2-independent growth of HTLV-I-transformed T cells in vitro and in the development of ATLL in vivo, but is not induced by STAT activation. 11503967 2001
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE High rate of chromosomal abnormalities in HTLV-I-infected T-cell colonies derived from prodromal phase of adult T-cell leukemia: a study of IL-2-stimulated colony formation in methylcellulose. 9973953 1999
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE Human thioredoxin (hTRX)/adult T-cell leukemia (ATL)-derived factor (ADF) was originally reported as an interleukin-2 (IL-2) receptor-alpha-inducing factor produced by human T-cell lymphotropic virus-1-positive (HTLV-1+) cell lines. 11228744 1999
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE Alteration of p16 (CDKN2) gene is associated with interleukin-2-induced tumor cell growth in adult T-cell leukemia. 10378889 1999
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 AlteredExpression disease BEFREE Adult T cell leukemia (ATL) is an aggressive malignancy that is associated with HTLV-I infection and characterized by constitutive expression of the high-affinity interleukin-2 receptor. 9356333 1997
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE Analysis of RNA from HTLV-I-infected cells established from patients with adult T cell leukemia (ATL) as well as tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) and both IL-2-dependent and IL-2-independent HTLV-I-infected cell lines by RNase protection has confirmed the existence of all of the alternatively spliced messages in each cell line analyzed. 9177442 1997
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 AlteredExpression disease BEFREE We could not detect human T cell leukemia virus type I (HTLV-I) mRNA or interleukin 2 (IL-2) mRNA in either the tumor cells growing in mice or the original leukemic cells. 8878449 1996
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE These results suggest that malignant growth of primary tumor cells in lymph nodes may be associated with the IL-2-IL-2 receptor system in patients with ATL more frequently than had been previously thought. 8628012 1996