Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE High CD70 expression was observed on CD4 + CD25+ T cells from patients with acute-type ATL, while patients with smoldering- or chronic-type ATL and HTLV-1 carriers exhibited lower expression. 26077361 2016
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Adult T cell leukemia/lymphoma (ATL) is an aggressive cancer of CD4/CD25(+) T lymphocytes, the etiological agent of which is human T-cell lymphotropic virus type 1 (HTLV-1). 26378177 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes. 26205403 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of CD4+CD25+ lymphocytes caused by human T-cell lymphotropic virus type 1. 24890041 2014
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Adult T-cell leukemia (ATL) is an aggressive malignancy of CD4(+)CD25(+) lymphocytes caused by human T-cell lymphotropic virus type 1. 23321252 2013
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE To identify novel therapeutic targets and diagnostic markers for ATL, we employed focused proteomic profiling of the CD4(+)CD25(+)CCR4(+) T-cell subpopulation in which HTLV-1-infected cells were enriched. 23538341 2013
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Adult T-cell leukaemia-lymphoma (ATLL) is an aggressive malignancy of CD4(+)  CD25(+) T lymphocytes, characterized by a severely compromised immunosystem, in which the human T-cell lymphotropic virus type 1 (HTLV-1) has been recognized as the aetiological agent. 23278479 2013
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE In flow cytometric analysis, the percentages of CD4(+)CADM1(+) double-positive cells correlated well with both the percentages of CD4(+)CD25(+) cells and with abnormal lymphocytes in the peripheral blood of patients with various types of ATLL. 22289924 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE In the present study, we show that an IκB kinase 2 (IKK2) inhibitor, IMD-0354, efficiently inhibits the survival of CD4(+) CD25(+) primary ATL cells and prevents the growth of or induces apoptosis of patient-derived ATL cell lines. 21951590 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Antibody therapy against ATL was initially started with interleukin-2 receptor α-subunit, CD25, as a target molecule in the late 1980s, and is currently ongoing. 21993874 2011
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Furthermore, the capacity of ATLL cells to suppress proliferation of heterologous CD4(+)CD25(-) cells correlated with the frequency of CD4(+) FoxP3(+) cells but was independent of CD25 expression. 19544530 2009
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 PosttranslationalModification disease BEFREE Human T-cell lymphotropic virus (HTLV-1) is linked to the development of adult T-cell leukemia/lymphoma (ATLL), which frequently expresses CD25. 19864230 2009
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 AlteredExpression disease BEFREE Leukemic (ATL) T cells constitutively expressing CD25 were characteristic of heterogeneous Foxp3 expression, such as intra- and inter-case heterogeneity in intensity, inconsistency with CD25 expression, and a discrepancy in the mRNA and its protein expression. 18510697 2008
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 AlteredExpression disease BEFREE Since most ATLL cells express both CD4 and CD25, these tumors might originate from CD4(+)CD25(+)FOXP3(+) Treg cells, based on their phenotypic characteristics. 17278106 2007
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Adult T-cell leukemia/lymphoma (ATL) is a peripheral CD4(+)CD25(+) T-cell malignancy caused by human T-cell leukemia virus type I. 15788694 2005
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4(+)CD25(+) phenotype. 15198736 2004
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 AlteredExpression disease BEFREE Comparisons of the transcriptional and translational levels of interleukin-2 receptor alpha chain (IL-2R alpha), transforming growth factor-beta 1 (TGF-beta 1) and intracellular adhesion molecule-1 (ICAM-1) in ATL, HAM/TSP, and SPC and in several control populations revealed selectively up-regulated expression in ATL. 9209305 1997
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE A polymerase chain reaction (PCR) method was used to detect the interleukin-2 receptor alpha-chain (IL-2R alpha) chain which lacks the conventional transmembrane (TM) domain in mRNA from human T-cell leukaemia virus type-I (HTLV-I)-infected cell lines or peripheral blood mononuclear cells (PBMC) isolated from adult T-cell leukaemia (ATL) patients. 9203962 1997
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE The surface phenotype showed that both the original leukemic cells and the WHN2 cells had a common phenotype of ATL, i.e., positive for CD2, CD4, human leukocyte antigen DR (HLA-DR) and CD25, but negative for CD8, a characteristic of helper/inducer T-cells. 8390425 1993
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 AlteredExpression disease BEFREE The tumor cells represented outgrowth of the original ATL leukemic clone in that they had monoclonal or oligoclonal integrations of the HTLV-I provirus identical to the leukemic clone and predominantly expressed the cell surface markers, CD4 and CD25. 8338942 1993
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 Biomarker disease BEFREE Adult T-cell leukemia (ATL) cells have been shown to express the receptor for IL-2 by studies using anti-CD25 monoclonal antibody, but these cells usually show no or only a weak proliferative response to IL-2. 1861543 1991
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 AlteredExpression disease BEFREE Human T cell lymphotropic virus-I (HTLV-I) associated Japanese, Carribean, and sporadic adult T cell leukemia/lymphomas usually express pan-T cell antigens, the CD4+ CD8- phenotype, and various T cell-associated activation antigens, including the interleukin-2 receptor (CD25). 2495724 1989
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 AlteredExpression disease BEFREE Normal resting T cells and most leukemic T-cell populations examined did not express IL-2 receptors; however, the leukemic cells of all patients with human T-cell lymphotrophic virus (HTLV-I)-associated adult T-cell leukemia (ATL) expressed the Tac antigen. 2888269 1987
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 AlteredExpression disease BEFREE The expression of Tac antigen, investigated in 27 cases of human T cell leukemia virus I-negative chronic T cell leukemia, which included the 15 cases of T-PLL, showed a good correlation with abnormalities of 7q35. 3115337 1987
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.100 AlteredExpression disease BEFREE In HTLV-I transformed T-cell lines established from the patients with adult T-cell leukemia (ATL), there is a constitutive activation of the normal IL-2 receptor (IL-2-R) gene. 2889666 1987