Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. 30057145 2018
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE To elucidate the target of IRF4 and c-Rel in ATLL, we determined the simultaneous binding sites of IRF4 and c-Rel using ChIP-seq technology. 29684346 2018
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE IRF4 may represent a therapeutic target in ATL because ATL cells select for a mutant of IRF4 with higher nuclear expression and transcriptional activity, and overexpression of IRF4 induces the expansion of T lymphocytes <i>in vivo</i>. 29540473 2018
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways. 28910419 2017
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease CTD_human Integrated molecular analysis of adult T cell leukemia/lymphoma. 26437031 2015
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 AlteredExpression disease BEFREE Furthermore, the level of IRF4 mRNA is significantly correlated with that of BIC in adult T-cell lymphoma/leukemia (ATLL) tumors. 21680528 2011
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 AlteredExpression disease BEFREE IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma. 17138822 2007
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 AlteredExpression disease BEFREE We have examined the specific mechanisms underlying the expression and regulation of the IRF-4 transcription factor in HTLV-I-infected cells and have shown that constitutive IRF-4 expression is exclusive to the transformed, leukemic ATL phenotype as opposed to the nonleukemic HTLV-I associated myelopathies/tropical spastic paraparesis (HAM/TSP) phenotype. 11846984 2002
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 GeneticVariation disease BEFREE All HTLV-1 infected cell lines and ATL patient lymphocytes demonstrated a dramatic decrease in cyclin B1 levels; subsequent analysis of the cyclin B1 promoter identified two sites important in IRF-4 binding and repression of cyclin B1 expression. 12360402 2002
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease LHGDN Taken together, our results indicate that IRF4 is involved in the pathogenesis of ATL through its positive effect on the cell cycle, and that IRF4 can be used as a molecular marker of clinical subtype in ATL. 11749693 2001
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE Taken together, our results indicate that IRF4 is involved in the pathogenesis of ATL through its positive effect on the cell cycle, and that IRF4 can be used as a molecular marker of clinical subtype in ATL. 11749693 2001
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE Also, MUM1 was stained at high intensity in various types of T cell lymphomas including adult T cell leukemia/lymphoma (ATL/L) and anaplastic large cell lymphoma (ALCL) and in the majority of Hodgkin's diseases. 10720141 2000