| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | disease | BEFREE | Gain-of-function NOTCH1 mutations are prevalent in human T-cell leukemia, while loss of Notch signaling is reported in myeloid leukemias. | 30206308 | 2019 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | A Novel t(8;14)(q24;q11) Rearranged Human Cell Line as a Model for Mechanistic and Drug Discovery Studies of NOTCH1-Independent Human T-Cell Leukemia. | 30304769 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | Our results suggest that targeting JAG1 can block Notch1 activation in HTLV-I-transformed cells and represents a new target for immunotherapy in ATL patients. | 30231940 | 2018 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | We have previously described the presence of Notch1 activating mutations and constitutive Notch1 signaling in patients with acute ATL. | 27247421 | 2016 | ||||
|
0.090 | Biomarker | disease | BEFREE | These data suggest that activated Notch may be important to ATL pathogenesis and reveal Notch1 as a target for therapeutic intervention in ATL patients. | 20823234 | 2010 | ||||
|
0.090 | AlteredExpression | disease | LHGDN | Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1. | 17874453 | 2008 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | We also analyzed the expression of NOTCH1 target genes (HES1, CCND1, and MYC), all of which were expressed in the sample of the PTCL-u patient with the NOTCH1 mutation, but found only MYC to be expressed in the sample from the ATL patient. | 17483057 | 2007 | ||||
|
0.090 | Biomarker | disease | BEFREE | Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice. | 9111040 | 1997 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Translocation-associated Notch homologue (TAN-1), a gene originally cloned from the translocation breakpoint of a human T cell leukemia carrying a 9:7(q34.3) translocation, encodes a protein belonging to the Notch/Lin-12/Glp-1 receptor family. | 8642313 | 1996 |