Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.040 Biomarker disease BEFREE Deregulated oncogenic signaling linked to PI3K/AKT and mTORC1 pathway activation is a hallmark of human T cell acute leukemia (T-ALL) pathogenesis and contributes to leukemic cell resistance and adverse prognosis. 31744878 2020
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.040 Biomarker disease BEFREE These results indicate that the PI3K/mTOR pathway is critical to ATL-cell proliferation and might thus be a new therapeutic target in ATL. 29077243 2018
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.040 Biomarker disease BEFREE Therefore, NDRG2 works as a PP2A recruiter to suppress not only PI3K/AKT signaling but also NF-κB signaling, which is particularly important in host defenses or immune responses to Human T-cell leukemia virus type 1 (HTLV-1) infection. 26269411 2015
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.040 PosttranslationalModification disease BEFREE Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. 24569712 2014