| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | Thus, our study reveals a novel molecular mechanism involving changes in three-dimensional chromatin interactions that activate the TAL1 oncogene in human T-cell leukemia. | 23698277 | 2014 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. | 22982397 | 2012 | ||||
|
0.090 | Biomarker | disease | BEFREE | tal-1 (T-cell acute leukemia-1; also known as SCL) and tal-2 genes belong to a family of basic helix-loop-helix transcription factors and were originally isolated from the breakpoints of chromosomal translocations in human T-cell leukemia cell lines. tal-1 is expressed not only in hematopoietic cells but also in several endothelial structures and the central nervous system during development. | 9931488 | 1999 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Rearrangement of the tal-1 gene is the most frequent clonal marker in childhood T cell acute leukemia. | 9211539 | 1997 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | A comparative study of the immunohistochemical (Stem cell leukemia/T-cell acute leukemia [SCL/TAL-1] protein expression) and genotypic (deletions in the SCL/tal-1 gene) findings in T-acute lymphoblastic leukemia (T-ALL) is presented. | 7672800 | 1995 | ||||
|
0.090 | Biomarker | disease | BEFREE | A complex containing both RBTN1 and TAL1 also occurs in a T-cell acute leukemia cell line. | 8078932 | 1994 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | The translocation (1;14)(p34;q11) in human T-cell leukemia: chromosome breakage 25 kilobase pairs downstream of the TAL1 protooncogene. | 1382561 | 1992 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. | 2230650 | 1990 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. | 2209547 | 1990 |