Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 AlteredExpression disease BEFREE None of the other covariates-for example, age, body weight, body mass index, bilirubin, creatinine clearance, disease type (ATL and CTCL), ATL subtype (acute, lymphoma, and chronic), CTCL subtype (mycosis fungoides and Sézary syndrome), CCR4 expression (status or degree), race (Japanese and non-Japanese), renal impairment (normal, mild, moderate, and severe), or performance status-had a statistically significant impact. 31840838 2020
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE This prospective, observational, postmarketing surveillance was conducted to evaluate the safety and effectiveness of mogamulizumab, an anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, in patients with CCR4-positive, relapsed or refractory (r/r) adult T-cell leukemia-lymphoma (ATL) in Japan. 30740787 2019
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 GeneticVariation disease BEFREE This study suggests that frequencies of CCR4 expression and genomic CCR4 mutations and an association between the two may be considerably different between ATL cases and non-ATL T/NK-cell lymphomas. 31468320 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE T-LGLL and ATL share dependence on IL-2 and IL-15 for survival and both diseases lack effective therapies. 30353031 2019
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 AlteredExpression disease BEFREE CCR4 is expressed in almost all cases of ATLL, and in a majority of CTCLs, particularly when blood involvement is present. 30799938 2019
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE The anti-CCR4 mAb, mogamulizumab, offers therapeutic benefit to patients with adult T-cell leukemia-lymphoma (ATL), but skin-related adverse events (AE) such as erythema multiforme occur frequently. 31018922 2019
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE Mogamulizumab, an anti-CCR4 monoclonal antibody, and lenalidomide, an immunomodulatory drug, are approved for ATL in Japan. 30047026 2018
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 AlteredExpression disease BEFREE Although the anti-CCR4 antibody mogamulizumab (moga) shows striking antitumor activity against adult T cell leukemia (ATL), it can also cause fatal immunological pathology such as severe skin rash and graft-versus-host disease, which might be attributed to depletion of CCR4<sup>+</sup> regulatory T cells. 29399406 2018
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3
0.400 Biomarker disease BEFREE The FOXP3 in ATLLs (41.02 ± 24.2) was more than ACs (1.44 ± 1) (P = 0.007) and HAM/TSP (0.45 ± 0.15) (P = 0.01). 30577817 2018
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. 30057145 2018
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE To elucidate the target of IRF4 and c-Rel in ATLL, we determined the simultaneous binding sites of IRF4 and c-Rel using ChIP-seq technology. 29684346 2018
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE IRF4 may represent a therapeutic target in ATL because ATL cells select for a mutant of IRF4 with higher nuclear expression and transcriptional activity, and overexpression of IRF4 induces the expansion of T lymphocytes <i>in vivo</i>. 29540473 2018
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3
0.400 AlteredExpression disease BEFREE The Foxp3 expression was similar in ATL and HAMSS, but significantly higher in HAM-SS than AC-SS (p<0.05). p65 was expressed in LSG MNC nuclei from all SS patients and co-expressed with Foxp3. 29600938 2018
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T-cell leukaemia/lymphoma (ATLL), followed by cutaneous T-cell lymphoma and peripheral T-cell lymphoma. 29341283 2018
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE Human T-cell leukemia virus type 1 (HTLV-1) infects mainly CD4+CCR4+ effector/memory T cells in vivo. 29186194 2017
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE The present study sought to elucidate the prognosis of adult T-cell leukemia-lymphoma (ATL) patients receiving mogamulizumab, a defucosylated anti-CCR4 monoclonal antibody. 28776876 2017
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE Areas covered: Mogamulizumab is a humanized, defucosylated monoclonal antibody that acts by targeting the CC chemokine receptor 4 (CCR4) on malignant cells of ATL. 28756726 2017
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE Mogamulizumab, an anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, is one of the promising agents for CCR4-positive T-cell lymphomas, especially for ATL. 28649848 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE BAY 1143572-treated ATL-bearing mice (once daily 12.5 mg/kg oral application) demonstrated significantly decreased ATL cell infiltration of the liver and bone marrow, as well as decreased human soluble interleukin-2 receptor levels in serum (reflecting the ATL tumor burden), compared with untreated mice (n = 8 for both). 28646117 2017
Entrez Id: 3662
Gene Symbol: IRF4
IRF4
0.400 Biomarker disease BEFREE IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways. 28910419 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker disease BEFREE In this study, by using IL-2-dependent HTLV-1-infected T-cell lines (ILTs) established from patients with ATL and HAM/TSP, we demonstrate that the anti-inflammatory cytokine IL-10 and its downstream signals potentially act as a switch for proliferation in HTLV-1-infected cells. 28910419 2017
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE Galectin-9 as a Predictive Marker for the Onset of Immune-Related Adverse Effects Associated with Anti-CCR4 MoAb Therapy in Patients with Adult T Cell Leukemia. 28321034 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 GeneticVariation disease BEFREE Transforming activity was further demonstrated by the ability of the FBXW7 D510E mutant to provide IL-2-independent growth of Tax-immortalized human T cells and increase the tumor formation in a xenograft mouse model of ATL. 27247421 2016
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 Biomarker disease BEFREE Mogamulizumab (Mog), a humanized anti-CC chemokine receptor 4 (CCR4) mAb that mediates antibody-dependent cellular cytotoxicity (ADCC) using FcγR IIIa (CD16)-expressing effector cells, has recently been approved for treatment of CCR4-positive adult T-cell leukemia (ATL) in Japan. 27091408 2016
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.400 GeneticVariation disease BEFREE Furthermore, among ATLL cases, FS mutation was significantly associated with a poor prognosis, compared with NS mutation and WT CCR4. 26847489 2016