Gene: NUDT15 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15 		0.200 GeneticVariation disease BEFREE There are 6/69 (8.7%) patients who developed leukopenia and harbored NUDT15 variant, thus showing a strong association for thiopurine-induced toxicity. 27416873 2017
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15 		0.200 Biomarker disease BEFREE TPMT and NUDT15 gene sequencing was performed for patients who had experienced AZA-induced leukopenia. 26735160 2016
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15 		0.200 GeneticVariation disease BEFREE NUDT15 c.415C>T may be another predictor of AZA-induced leukocytopenia. 27381176 2016
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15 		0.200 GeneticVariation disease BEFREE In a recent study, NUDT15 R139C was strongly associated with thiopurine-induced leukopenia in Korean and Caucasian populations. 26076924 2016
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15 		0.200 GeneticVariation disease BEFREE NUDT15 R139C was strongly associated with the incidence of leukopenia (70.2% mutation vs. 12.8% wild type; P=8.61×10<sup>-19</sup> ; odds ratio, 10.80; 95% CI, 5.89-19.83). 27604507 2016
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15 		0.200 GeneticVariation disease BEFREE NUDT15 R139C was significantly associated with early (<8 weeks) (P = 1.03 × 10(-4)) and late (>8 weeks) leukocytopenia (P = 4.3 × 10(-4)). 26590936 2016
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15 		0.200 GeneticVariation disease BEFREE In particular, SNPs in NUDT15 and in the class II HLA locus have been shown to predict thiopurine-related leukopenia and pancreatitis. 26067482 2015
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15 		0.200 Biomarker disease BEFREE Thus, NUDT15 is a pharmacogenetic determinant for thiopurine-induced leukopenia in diverse populations. 25108385 2014
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15 		0.200 GeneticVariation disease GWASCAT A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. 25108385 2014