| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.570 | GeneticVariation | disease | BEFREE | Polymorphism in the Promoter Region of NFE2L2 Gene Is a Genetic Marker of Susceptibility to Cirrhosis Associated with Alcohol Abuse. | 31340446 | 2019 | ||||
|
0.570 | Biomarker | disease | BEFREE | Therefore, in the present work, the capacity of doxazosin (<i>α</i>1 antagonist), carvedilol (nonselective beta-adrenoceptor blocker with alpha 1-blocking properties), and curcumin (antioxidant and anti-inflammatory compound) to reverse liver cirrhosis and studying the possible modulation of Nrf-2 and NF-<i>κ</i>B were evaluated. | 31183386 | 2019 | ||||
|
0.570 | Biomarker | disease | BEFREE | Integrated stress response in hepatitis C promotes Nrf2-related chaperone-mediated autophagy: A novel mechanism for host-microbe survival and HCC development in liver cirrhosis. | 31386899 | 2019 | ||||
|
0.570 | Biomarker | disease | BEFREE | Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis. | 29852187 | 2018 | ||||
|
0.570 | AlteredExpression | disease | BEFREE | PBC was associated with reduced Nrf2 expression and autophagy deterioration and these impairments were more advanced in patients with cirrhosis. | 28333129 | 2017 | ||||
|
0.570 | Biomarker | disease | BEFREE | Finally, we showed the therapeutic importance of targeting Hrd1, rather than Keap1, to prevent Nrf2 loss and suppress liver cirrhosis. | 24636985 | 2014 | ||||
|
0.570 | Therapeutic | disease | CTD_human | Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis. | 23793039 | 2013 | ||||
|
0.570 | AlteredExpression | disease | BEFREE | It remains to be established in further studies if the observed decrease of Nrf2 expression is just a result of liver cirrhosis or is primary, playing a role in disease pathogenesis. | 22459801 | 2012 | ||||
|
0.570 | Therapeutic | disease | RGD | Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats. | 22732220 | 2012 |