Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23022
Gene Symbol: PALLD
PALLD
0.100 Biomarker group HPO
Entrez Id: 91147
Gene Symbol: TMEM67
TMEM67
0.100 Biomarker group HPO
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.100 Biomarker group HPO
Entrez Id: 5978
Gene Symbol: REST
REST
0.100 Biomarker group HPO
Entrez Id: 4665
Gene Symbol: NAB2
NAB2
0.100 Biomarker group HPO
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.100 Biomarker group HPO
Entrez Id: 9319
Gene Symbol: TRIP13
TRIP13
0.100 Biomarker group HPO
Entrez Id: 283120
Gene Symbol: H19
H19
0.100 Biomarker group HPO
Entrez Id: 23322
Gene Symbol: RPGRIP1L
RPGRIP1L
0.100 Biomarker group HPO
Entrez Id: 57545
Gene Symbol: CC2D2A
CC2D2A
0.100 Biomarker group HPO
Entrez Id: 3821
Gene Symbol: KLRC1
KLRC1
0.010 Biomarker group BEFREE <i>Conclusions</i>: These findings indicate that NKG2A expression is influenced by factors from cancer nests and contributes to NK cell exhaustion, suggesting that NKG2A blockade has the potential to restore immunity against liver tumors by reversing NK cell exhaustion. 28197391 2017
Entrez Id: 3925
Gene Symbol: STMN1
STMN1
0.020 Biomarker group BEFREE <i>miR-223</i> and Stathmin-1 Expression in Non-tumor Liver Tissue of Patients with Hepatocellular Carcinoma. 28982915 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker group BEFREE <i>RSPO2</i> gene rearrangement: a powerful driver of β-catenin activation in liver tumours. 30901310 2019
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.030 Biomarker group BEFREE <i>SAMMSON</i> drives the self-renewal of liver tumor initiating cells through EZH2-dependent Wnt/β-catenin activation. 29262600 2017
Entrez Id: 6502
Gene Symbol: SKP2
SKP2
0.240 Biomarker group BEFREE <i>Schistosoma japonicum</i> MiRNA-7-5p Inhibits the Growth and Migration of Hepatoma Cells via Cross-Species Regulation of S-Phase Kinase-Associated Protein 2. 30967999 2019
Entrez Id: 142
Gene Symbol: PARP1
PARP1
0.040 Biomarker group BEFREE <i>T.Diversifolia</i> leaves were first extracted in ethyl acetate, then further fractionated by different ratio of <i>n</i>-hexane/ethyl acetate (8:2→0:1) or methanol.These extracts exhibit growth inhibition on human hepatoma (HCC) HepG2 cells.<i>n</i>-Hexane/ethyl acetate (6:4) extract (Td-F2) induces apoptosis of HCC.<b>Abbreviations used:</b><i>T. diversifolia</i>, <i>Tithonia diversifolia</i>; HCC, Hepatocellular carcinoma DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; HRP, horseradish peroxidase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; OD, optical density; SDS-PAGE, sodium dodecylsulfate-polyacrylamide gel electrophoresis; PARP, Poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PI, propidium iodide. 29200736 2019
Entrez Id: 1302
Gene Symbol: COL11A2
COL11A2
0.030 Biomarker group BEFREE <i>T.Diversifolia</i> leaves were first extracted in ethyl acetate, then further fractionated by different ratio of <i>n</i>-hexane/ethyl acetate (8:2→0:1) or methanol.These extracts exhibit growth inhibition on human hepatoma (HCC) HepG2 cells.<i>n</i>-Hexane/ethyl acetate (6:4) extract (Td-F2) induces apoptosis of HCC.<b>Abbreviations used:</b><i>T. diversifolia</i>, <i>Tithonia diversifolia</i>; HCC, Hepatocellular carcinoma DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; HRP, horseradish peroxidase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; OD, optical density; SDS-PAGE, sodium dodecylsulfate-polyacrylamide gel electrophoresis; PARP, Poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PI, propidium iodide. 29200736 2019
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.010 Biomarker group BEFREE <i>T.Diversifolia</i> leaves were first extracted in ethyl acetate, then further fractionated by different ratio of <i>n</i>-hexane/ethyl acetate (8:2→0:1) or methanol.These extracts exhibit growth inhibition on human hepatoma (HCC) HepG2 cells.<i>n</i>-Hexane/ethyl acetate (6:4) extract (Td-F2) induces apoptosis of HCC.<b>Abbreviations used:</b><i>T. diversifolia</i>, <i>Tithonia diversifolia</i>; HCC, Hepatocellular carcinoma DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; HRP, horseradish peroxidase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; OD, optical density; SDS-PAGE, sodium dodecylsulfate-polyacrylamide gel electrophoresis; PARP, Poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PI, propidium iodide. 29200736 2019
Entrez Id: 1131
Gene Symbol: CHRM3
CHRM3
0.010 Biomarker group BEFREE <i>T.Diversifolia</i> leaves were first extracted in ethyl acetate, then further fractionated by different ratio of <i>n</i>-hexane/ethyl acetate (8:2→0:1) or methanol.These extracts exhibit growth inhibition on human hepatoma (HCC) HepG2 cells.<i>n</i>-Hexane/ethyl acetate (6:4) extract (Td-F2) induces apoptosis of HCC.<b>Abbreviations used:</b><i>T. diversifolia</i>, <i>Tithonia diversifolia</i>; HCC, Hepatocellular carcinoma DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; HRP, horseradish peroxidase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; OD, optical density; SDS-PAGE, sodium dodecylsulfate-polyacrylamide gel electrophoresis; PARP, Poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PI, propidium iodide. 29200736 2019
Entrez Id: 706
Gene Symbol: TSPO
TSPO
0.010 Biomarker group BEFREE <i>T.Diversifolia</i> leaves were first extracted in ethyl acetate, then further fractionated by different ratio of <i>n</i>-hexane/ethyl acetate (8:2→0:1) or methanol.These extracts exhibit growth inhibition on human hepatoma (HCC) HepG2 cells.<i>n</i>-Hexane/ethyl acetate (6:4) extract (Td-F2) induces apoptosis of HCC.<b>Abbreviations used:</b><i>T. diversifolia</i>, <i>Tithonia diversifolia</i>; HCC, Hepatocellular carcinoma DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; HRP, horseradish peroxidase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; OD, optical density; SDS-PAGE, sodium dodecylsulfate-polyacrylamide gel electrophoresis; PARP, Poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PI, propidium iodide. 29200736 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.030 Biomarker group BEFREE (111)In-NODAGA-Z(HER2:S1) provided higher tumour-to-blood ratio, but somewhat lower tumour-to-liver, tumour-to-spleen and tumour-to-bone ratios. 22322933 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE (b) Among peptides covering the entire sequence of human IL-6 and the corresponding antipeptide antibodies, the peptide IL-6[35-66] and anti-IL-6[35-66] most effectively inhibited the interaction between human hepatoma HepG2 cells and the preS(21-47) ligand, suggesting that this region of the human IL-6 sequence encompasses a binding site for the HBV env protein. 1334115 1992
Entrez Id: 100616442
Gene Symbol: ERVK-12
ERVK-12
0.010 Biomarker group BEFREE (b) Among peptides covering the entire sequence of human IL-6 and the corresponding antipeptide antibodies, the peptide IL-6[35-66] and anti-IL-6[35-66] most effectively inhibited the interaction between human hepatoma HepG2 cells and the preS(21-47) ligand, suggesting that this region of the human IL-6 sequence encompasses a binding site for the HBV env protein. 1334115 1992
Entrez Id: 100862688
Gene Symbol: ERVK-11
ERVK-11
0.010 Biomarker group BEFREE (b) Among peptides covering the entire sequence of human IL-6 and the corresponding antipeptide antibodies, the peptide IL-6[35-66] and anti-IL-6[35-66] most effectively inhibited the interaction between human hepatoma HepG2 cells and the preS(21-47) ligand, suggesting that this region of the human IL-6 sequence encompasses a binding site for the HBV env protein. 1334115 1992
Entrez Id: 100616100
Gene Symbol: ERVK-2
ERVK-2
0.010 Biomarker group BEFREE (b) Among peptides covering the entire sequence of human IL-6 and the corresponding antipeptide antibodies, the peptide IL-6[35-66] and anti-IL-6[35-66] most effectively inhibited the interaction between human hepatoma HepG2 cells and the preS(21-47) ligand, suggesting that this region of the human IL-6 sequence encompasses a binding site for the HBV env protein. 1334115 1992