| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | AlteredExpression | group | BEFREE | In previous studies on liver tumor tissues, PPARα mRNA expression was found to be significantly higher and overexpression of ERα inhibited the PPARα expression, cell-proliferation and also induced apoptosis in Hep3B cell. | 27757837 | 2017 | ||||
|
0.360 | GeneticVariation | group | BEFREE | Here, we evaluated DNA methylation at 3 candidate genes (Esr1, Il-6st, and Stat3) in liver tissue of BPA-exposed mice euthanized at 2 time points: post-natal day 22 (PND22; n = 147) or 10-months of age (n = 78, including n = 18 with hepatic tumors). | 26542749 | 2015 | ||||
|
0.360 | Biomarker | group | BEFREE | The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells. | 24481452 | 2014 | ||||
|
0.360 | Biomarker | group | CTD_human | Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen. | 16712894 | 2006 | ||||
|
0.360 | Biomarker | group | BEFREE | Stable transfection of the chimeric Gal4 estrogen receptor and luciferase gene constructs in MCF-7 breast cancer and Hepa.1c1c7 mouse hepatoma cell lines, as well as transfection of a newly constructed luciferase reporter gene pEREtata-Luc in the ECC-1 human endometrial cell line, resulted in constitutive, non-estradiol-inducible clones. | 10330684 | 1999 | ||||
|
0.360 | AlteredExpression | group | BEFREE | We also show that transcriptional activity of reporter constructs containing human angiotensinogen gene promoter with nucleoside A at -20 is increased on cotransfection of an expression vector containing human estrogen receptor-alpha coding sequence in human hepatoma cells (HepG2) followed by estrogen treatment. | 9931090 | 1999 | ||||
|
0.360 | Biomarker | group | BEFREE | Tamoxifen inhibits hepatoma cell growth through an estrogen receptor independent mechanism. | 8750171 | 1995 |