Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 Biomarker group BEFREE The MOA for permethrin-induced mouse liver tumor formation due to PPARα activation is considered to be not plausible for humans. 30629241 2019
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 Biomarker group CTD_human Fenofibrate induced PPAR alpha expression was attenuated by oestrogen receptor alpha overexpression in Hep3B cells. 29134746 2018
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 Biomarker group BEFREE PPARα activators are unlikely to induce liver tumors in humans due to biological differences in the response of KEs downstream of PPARα activation. 29197930 2018
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 Biomarker group BEFREE The objective of the present investigation was to evaluate the dependency of early key events leading to liver tumors on PPARα activation in wildtype (WT) compared to PPARα-knockout (KO) rats following 2 weeks exposure to 75, 500 and 1000 ppm propaquizafop in the diet. 29626562 2018
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 AlteredExpression group BEFREE The mechanism for liver tumor induction has been attributed to activation of either peroxisome proliferator activated receptor α (PPARα) or constitutive androstane receptor (CAR). 28267557 2017
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 Biomarker group BEFREE Based on these studies, it was demonstrated that the liver tumors were mediated by a mode of action (MoA) involving nuclear receptors (NRs) through the following key events: (1) CAR and PPAR-α receptor activation, (2) increased hepatocellular proliferation, eventually leading to (3) hepatocellular tumors. 25092647 2014
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 Biomarker group BEFREE We showed that the C3 gene is the direct target for peroxisome proliferator-activated receptor α (PPARα) in human hepatoma HepG2 cells and mouse liver. 23168409 2013
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 Biomarker group CTD_human Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. 20143881 2010
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 SusceptibilityMutation group RGD PPAR-alpha L162V polymorphism in human hepatocellular carcinoma. 19119483 2008
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 Biomarker group BEFREE Differential action of 13-HPODE on PPARalpha downstream genes in rat Fao and human HepG2 hepatoma cell lines. 16216487 2006
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.580 AlteredExpression group BEFREE Incubation of human hepatoma HepG2 cells with the natural FXR ligand chenodeoxycholic acid (CDCA) as well as with the nonsteroidal FXR agonist GW4064 resulted in a significant induction of PPARalpha mRNA levels. 12554753 2003