| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.260 | Biomarker | group | BEFREE | Detection of surfactant proteins A and D (SP-A and SP-D) in the serum of patients with pulmonary diseases is thought to reflect an injury of the alveolar epithelial barrier and as such serve as a biomarker for these diseases.However, the data for SP-B are limited. | 29763900 | 2018 | ||||
|
0.260 | Biomarker | group | BEFREE | The pulmonary surfactant-associated protein (SFTPA1, SP-A) gene has been studied as a candidate gene for lung disease resistance in humans and livestock. | 25442010 | 2015 | ||||
|
0.260 | Biomarker | group | RGD | Relationship between pulmonary surfactant protein and lipid peroxidation in lung injury due to paraquat intoxication in rats. | 17616020 | 2007 | ||||
|
0.260 | Biomarker | group | BEFREE | Association of common haplotypes of surfactant protein A1 and A2 (SFTPA1 and SFTPA2) genes with severity of lung disease in cystic fibrosis. | 16429424 | 2006 | ||||
|
0.260 | GeneticVariation | group | BEFREE | Allelic variations of the SP-A and SP-B genes have been shown to be important genetic determinants in individual susceptibility to RDS, which is a good general model for a multifactorial pulmonary disease resulting from complex interactions between several environmental and genetic factors. | 12452477 | 2002 | ||||
|
0.260 | GeneticVariation | group | BEFREE | The heterozygosity indices and polymorphism information content values ranged between 0.50--0.62 indicating that SP-A gene locus is polymorphic enough for studies associating the locus with pulmonary diseases. | 11381191 | 2000 | ||||
|
0.260 | Biomarker | group | BEFREE | Therefore, the SP-A and SP-D genes make particularly good candidates to study factors contributing to pulmonary disease etiopathogenesis. | 9813381 | 1998 | ||||
|
0.260 | Biomarker | group | RGD | Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration. | 9374572 | 1997 |