| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | group | BEFREE | The overlap in risk genes in aging lung diseases provides evidence that processes associated with FAM13A, DSP and TERT are important for healthy aging. | 29517586 | 2018 | ||||
|
0.370 | Biomarker | group | BEFREE | Telomere length, RTEL1 and TERT expression may serve as potential biomarkers related to silica exposure and may offer insight into the molecular mechanism of silica-induced lung disease and tumorigeneses. | 29230030 | 2017 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Patients with documented TERT or TR mutations who received a lung transplant between 2007 and 2013 in France were identified via an exhaustive search of the lung transplantation network, one expert genetic laboratory, and the clinical research network on rare pulmonary diseases. | 25612863 | 2015 | ||||
|
0.370 | Biomarker | group | BEFREE | Mutations of human telomerase RNA component (TERC) and telomerase reverse transcriptase (TERT) are associated with a subset of lung aging diseases, but the mechanisms by which TERC and TERT participate in lung diseases remain unclear. | 26518879 | 2015 | ||||
|
0.370 | Biomarker | group | BEFREE | Human telomerase reverse transcriptase (hTERT) gene amplification was detected in pleural effusions of patients with lung cancer (n = 69) and in patients with benign lung disease (n = 46) when using a quantitative polymerase chain reaction (qPCR) technique. | 22464057 | 2012 | ||||
|
0.370 | GeneticVariation | group | BEFREE | In familial pulmonary fibrosis, asymptomatic preclinical alveolar inflammation associated with mutation in TERT and telomerase insufficiency can progress to fibrotic lung disease over 2 to 3 decades. | 20966039 | 2011 | ||||
|
0.370 | Biomarker | group | GENOMICS_ENGLAND | Telomerase mutations in families with idiopathic pulmonary fibrosis. | 17392301 | 2007 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Sequencing a candidate gene within the interval, TERT, revealed a missense mutation and a frameshift mutation that cosegregated with pulmonary disease in the two families. | 17460043 | 2007 |