Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE Fibroblasts undergoing replicative senescence or transforming growth factor β1-induced senescence and fibroblasts isolated from human subjects with an age-related lung disorder, idiopathic pulmonary fibrosis, secreted higher numbers of EVs than their respective controls. 30321056 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor prognosis and limited therapies, and transforming growth factor-β1 (TGF-β1) plays a central role in the pathogenesis of IPF. 31606345 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE Elevated levels of TGF-β1 are found in patients with acute and chronic lung diseases, and the underlying disease processes are exacerbated by respiratory viral infections. 29427413 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE While the serum and BALF levels of KL-6 and TGF-β2 are not highly specific, TGF-β1 may be a valuable reference diagnostic marker in HM lung disease. 29669483 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE The significant Ago2-IP enrichment of targets of these miRNAs related to the TGF-β and/or Wnt pathways (NGF, DLD, HHEX) in TGF-β1-stimulated fibroblasts suggest a role for these miRNAs in lung diseases by affecting lung fibroblast function. 28910321 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE High-producer TGFβ1 genotypes are associated with severe lung disease in cystic fibrosis (CF), but studies combining IL-8, TNFα-, and TGFβ1(+genotype) levels and their impact on CF lung disease are scarce. 24062613 2013
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE In contrast, pathogenesis of other chronic lung diseases like ΔF508-cystic fibrosis (CF), α1-anti-trypsin-deficiency (α-1 ATD) and pulmonary fibrosis (PF) is regulated by other proteostatic mechanisms, involving the degradation of misfolded proteins (ΔF508-CFTR/α1-AT- Z variant) or regulating the concentration of signaling proteins (such as TGF-β1) by the ubiquitin-proteasome system (UPS). 22697347 2012
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE These data suggest that the beneficial anti-fibrotic effects of SAP in TGFβ(1)-induced lung disease are via modulating monocyte responses. 21044893 2011
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group RGD Early administration of propofol protects against endotoxin-induced acute lung injury in rats by inhibiting the TGF-beta1-Smad2 dependent pathway. 19941153 2010
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group RGD Pyrrolidine dithiocarbamate attenuates paraquat-induced lung injury in rats. 19639047 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE In summary, the results confirm the hypothesis that TGF-beta1 polymorphisms are associated with asbestos-induced fibrotic or malignant lung diseases in whites. 19349911 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE Analysis of the T869C polymorphism in the TGF-beta1 gene showed an association only between TC heterozygotes and mild pulmonary disease. 19466271 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE These findings support the concept that TGFB1 gene variants appear to be important genetic modifiers of lung disease progression in CF. 19009622 2008
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group LHGDN These findings provide evidence of gene-gene interaction in the pathogenesis of CF lung disease, whereby high TGF-beta1 production enhances the modulatory effect of MBL2 on the age of first bacterial infection and the rate of decline of pulmonary function. 18292811 2008
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE These results demonstrate that TGFB1 is a modifier of CF lung disease and reveal a previously unrecognized beneficial effect of TGFB1 variants upon the pulmonary phenotype. 18424453 2008
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE TGF-beta1, a cytokine involved in mediating the fibrotic/Th1 response, has several genetic variants which might predispose individuals to these lung diseases. 17785866 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE Emerging data indicate that non-CFTR genetic variants contribute to at least half the variability in pulmonary disease severity, and genetic variation in transforming growth factor beta1 clearly modifies the severity of cystic fibrosis lung disease. 17053491 2006
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE This study examined whether or not components of the Shh signalling pathway, as well as TGF-beta1, are expressed in human fibrotic lung disease (cryptogenic fibrosing alveolitis and bronchiectasis) and in murine experimental models of fibrotic and non-fibrotic chronic pulmonary inflammation. 12635140 2003
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE Two anti-inflammatory cytokines, interleukin-1 receptor antagonist and transforming growth factor-beta1, had increased expression, consistent with other human fibrotic lung diseases and animal models of lung fibrosis. 11970906 2002
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group CTD_human Before these experiments, there was no information available that would provide a basis for predicting whether or not TGF-beta(1) expression induces fibroproliferative lung disease in fibrogenic-resistant TNF-alphaRKO mice, an increasingly popular animal model. 11472967 2001