Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.080 | Biomarker | group | BEFREE | Detection of surfactant proteins A and D (SP-A and SP-D) in the serum of patients with pulmonary diseases is thought to reflect an injury of the alveolar epithelial barrier and as such serve as a biomarker for these diseases.However, the data for SP-B are limited. | 29763900 | 2018 | ||||
|
0.080 | Biomarker | group | BEFREE | The pulmonary surfactant-associated protein (SFTPA1, SP-A) gene has been studied as a candidate gene for lung disease resistance in humans and livestock. | 25442010 | 2015 | ||||
|
0.080 | Biomarker | group | BEFREE | Future areas for clinical research include disease specific SP-A expression pattern and their functional consequences, the differential roles of SP-A1 and SP-A2 in human lung diseases, and therapeutical approaches to correct altered SP-A levels. | 17168848 | 2006 | ||||
|
0.080 | Biomarker | group | BEFREE | Association of common haplotypes of surfactant protein A1 and A2 (SFTPA1 and SFTPA2) genes with severity of lung disease in cystic fibrosis. | 16429424 | 2006 | ||||
|
0.080 | AlteredExpression | group | LHGDN | [Pseudomonas aeruginosa and Surfactant-associated Proteins A and D]. | 16406431 | 2006 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Allelic variations of the SP-A and SP-B genes have been shown to be important genetic determinants in individual susceptibility to RDS, which is a good general model for a multifactorial pulmonary disease resulting from complex interactions between several environmental and genetic factors. | 12452477 | 2002 | ||||
|
0.080 | GeneticVariation | group | BEFREE | The heterozygosity indices and polymorphism information content values ranged between 0.50--0.62 indicating that SP-A gene locus is polymorphic enough for studies associating the locus with pulmonary diseases. | 11381191 | 2000 | ||||
|
0.080 | Biomarker | group | BEFREE | Therefore, the SP-A and SP-D genes make particularly good candidates to study factors contributing to pulmonary disease etiopathogenesis. | 9813381 | 1998 |