Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.350 Biomarker disease BEFREE These results suggest that FoxO3 plays a pivotal role in regulation of lung inflammatory response and antioxidant genes, and deficiency of FoxO3 results in development of chronic obstructive pulmonary disease/emphysema. 21690325 2011
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.350 Biomarker disease BEFREE UPS signaling was unaltered, whereas indices of UPS regulation (eg, FOXO1 protein; p-FOXO3/FOXO3), autophagy signaling (eg, LC3BII/I; p-ULK1[Ser757]/ULK1), and protein synthesis signaling (eg, AKT1; p-GSK3B/GSK3B; p-4E-BP1/4E-BP1) were increased in COPD. 28578881 2017
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.350 Biomarker disease BEFREE LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease. 28339038 2017
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.350 AlteredExpression disease BEFREE Similar protective effects of Vam3, reducing autophagy and restoring the levels of Sirt1 and FoxO3a, were observed in the COPD animal model. 22705731 2012
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.350 AlteredExpression disease BEFREE In PBECs, the constitutive FoxO3 expression was lower in patients with COPD than in controls. 29411515 2018
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.350 Biomarker disease CTD_human Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt. 23099361 2013