Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease GWASCAT Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. 30804561 2019
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease BEFREE <b>Areas covered</b>: The most relevant features of preclinical models of COPD, namely chronic exposure to CS and other agents (proteases and microorganisms), cardiovascular effects, surfactant protein-D, airway remodeling and inflammation, lung regeneration potential and mesenchymal stromal cell therapy are described. 31512957 2019
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease BEFREE The SP-D content in BALF has a potential to become a marker of COPD inflammatory activity and treatment monitoring. 30255302 2019
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease BEFREE High surfactant protein D (SP-D) concentrations in cord blood of IUGR foetuses/neonates could point to structural lung immaturity, resulting to asthma and chronic obstructive pulmonary disease in adult life. 31577039 2019
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease BEFREE Our objective was to assess the predictability of serum SFTPD concentration and SFTPD allelic conformation at rs721917 (C > T) with COPD and AECOPD outcome. 31057601 2019
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease BEFREE SP-D has been implicated in the development of respiratory diseases including respiratory distress syndrome, bronchopulmonary dysplasia, allergic asthma, and chronic obstructive pulmonary disease. 29473039 2018
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease CTD_human Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. 28166215 2017
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease GWASCAT Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. 28166215 2017
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease BEFREE SP-D is a promising therapeutic target for cachectic COPD patients with elevated circulating SP-D levels who are at increased risk of cardiovascular morbidity and mortality. 28472244 2017
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease BEFREE SP-D represents a very promising biomarker and therapeutic target for COPD. 29191953 2017
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease BEFREE Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD. 28791362 2017
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease BEFREE Some of these pQTLs [e.g., pQTLs for VDBP, sRAGE (gene = AGER), surfactant protein D (gene = SFTPD), and TNFRSF10C] have been previously associated with COPD phenotypes. 27532455 2016
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 AlteredExpression disease BEFREE The SP-D serum level and HLA-A gene frequency in COPD patients were significantly higher than those in healthy controls (13.62±2.09 ng/mL vs 10.28±2.86 ng/mL; 62.5% vs 12.5%; P<0.05). 26089660 2015
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 AlteredExpression disease BEFREE The serum levels of SP-D in COPD patients were significantly associated with the degree of airflow obstruction and frequency of exacerbation. 25376584 2015
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease BEFREE Polymorphisms in the SP-D-encoding gene SFTPD have been associated with chronic obstructive pulmonary disease and ulcerative colitis. 25716998 2015
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease BEFREE Carriers of the SFTPD AG and AA polymorphic genotypes constituted 71.4 % of COPD patients versus 48 % in asymptomatic smokers, with a statistically significant difference between the two groups (p = 0.049). 24504887 2014
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease BEFREE However, there was no evidence for any association between common polymorphisms in the SP-B and SP-D genes and COPD risk (all p>0.05). 24093802 2013
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease BEFREE We report for the first time that rs3088308 is an important factor influencing systemic SP-D levels and confirm the previous association of rs721917 to the risk of COPD and serum SP-D levels. 22846212 2012
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease BEFREE This suggests a protective effect of SFTPD against COPD and emphysema. 21934714 2012
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 AlteredExpression disease BEFREE Several SNPs highly associated with CC16 or SP-D levels were nominally associated with COPD in a collaborative GWAS (P = 0.001-0.049), although these COPD associations were not replicated in two additional cohorts. 23144326 2012
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease GWASCAT Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. 23144326 2012
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease BEFREE In the NETT-NAS case-control analysis, four SFTPD SNPs were associated with susceptibility to COPD: rs2245121 (P = 0.01), rs911887 (P = 0.006), rs6413520 (P = 0.004), and rs721917 (P = 0.006). 20448057 2011
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 GeneticVariation disease BEFREE Two SNPs in TGFB1 (C to T substitution at nucleotide -509 and substitution of leucine 10 with proline (Leu10Pro)), Leu50Val in SFTPA1 and Ala160Thr in SFTPD showed evidence suggestive of association with FEV(1)/IVC in subjects with GOLD stage >or=2 COPD. 19797132 2010
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 Biomarker disease RGD The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease. 18310480 2008
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD
0.700 AlteredExpression disease LHGDN Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. 18226251 2008