Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group BEFREE FISH with FHIT gene probe revealed deletions in cRCC (88%), breast (30%), and lung tumors (10%). 21962529 2013
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 AlteredExpression group BEFREE As TRAIL represents in the near future a good candidate for death ligands-based anticancer therapy, its potential therapeutic use should be envisaged as preliminary to molecular genetics interventions or drug-induced epigenetic modulations aimed to restoring FHIT gene expression levels in non-small cells lung tumors. 19418484 2009
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group BEFREE Sixty-two patients with suspected lung tumors were screened for variations within exons 5-9 of the FHIT gene using intronic primer pairs and single-strand conformation polymorphism and sequencing analysis. 19267103 2009
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 Biomarker group BEFREE The purpose of this study was to investigate the different molecular alterations leading to the inactivation of FHIT gene function and to validate their use as biomarkers of risk for progression of the disease in patients belonging to the multicentric European study for the Early detection of Lung Cancer (EUELC) who were resected for early-stage lung tumors. 19096006 2009
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 Biomarker group LHGDN FHIT and p53 status and response to platinum-based treatment in advanced non-small cell lung cancer. 18690840 2008
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 AlteredExpression group LHGDN Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells. 17328863 2007
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group BEFREE To further explore the molecular mechanisms between altered TSGs promoter methylation and overexpression of DNMTs protein, we performed a tissue chromatin-immunoprecipitation polymerase chain reaction assay for lung tumors and showed that the methylated FHIT, p16(INK4a) and RARbeta promoters were bound by both DNMT protein and methyl-CpG-binding protein 2. 17140695 2007
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group BEFREE There was concordance of HYAL2 or FHIT deletions in matched sputum and tumor tissues from lung cancer patients (r = 0.82, P = 0.04; r = 0.84, P = 0.03), suggesting that the genetic changes in sputum might indicate the presence of the same genetic aberrations in lung tumors. 17255269 2007
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group LHGDN Microsatellite analysis of induced sputum DNA in patients with lung cancer in heavy smokers and in healthy subjects. 17694439 2007
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 AlteredExpression group LHGDN FHIT protein enhances paclitaxel-induced apoptosis in lung cancer cells. 16231322 2006
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 PosttranslationalModification group LHGDN Loss of fragile histidine triad gene expression in advanced lung cancer is consequent to allelic loss at 3p14 locus and promoter methylation. 16513840 2006
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group LHGDN Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan. 15935551 2006
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 Biomarker group CTD_human Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. 16061637 2005
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 Biomarker group LHGDN MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis. 12169206 2003
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 Biomarker group LHGDN [Effects of ectogenous FHIT gene on reversing malignant phenotype of human lung adenocarcinoma cells A549]. 12048684 2002
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group LHGDN Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients. 11788890 2002
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 Biomarker group BEFREE This idea is supported by the more recent finding that FRA3B maps within the FHIT (fragile histadine triad) gene, and that aberrant transcripts and genomic deletions of FHIT/FRA3B occur in a variety of tumors including lung tumors. 12007194 2002
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 Biomarker group BEFREE When treated with DOTAP:Chol-p53 and -FHIT complex, significant suppression was observed in both primary (P < 0.02) and metastatic lung tumor growth (P < 0.007). 11273776 2001
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 Biomarker group CTD_human Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers. 10959838 2001
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group BEFREE We screened 40 primary lung tumors for the presence of point mutations within the coding exons of FHIT using PCR-single-strand conformational polymorphism. 9581816 1998
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group BEFREE Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus. 9662254 1998
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group BEFREE Abnormalities in structure and expression of the FHIT gene have been detected in a considerable fraction of primary lung tumors. 9850082 1998
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 AlteredExpression group BEFREE Using specific antibodies against the Fhit protein, we observed concordance between RNA abnormalities and lack of Fhit protein expression in lung tumors and cell lines. 9393735 1997
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 GeneticVariation group BEFREE To identify genetic lesions characteristic of tobacco damage, we undertook a molecular analysis of microsatellite alterations within the FHIT gene and FRA3B, as well as at an independent locus on chromosome 10, D10S197, in lung tumors from heavy smokers and in tumors from never smokers. 9187107 1997
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
0.400 AlteredExpression group BEFREE Small cell lung tumors (80%) and non-small cell lung cancers (40%) showed abnormalities in RNA transcripts of FHIT, and 76% of the tumors exhibited loss of FHIT alleles. 8620533 1996