| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | AlteredExpression | group | BEFREE | Overexpression of transcription factor forkhead box M1 (FOXM1) is involved in the inauspicious development of several types of cancer, including lung tumor aggressiveness. | 30499104 | 2019 | ||||
|
0.370 | AlteredExpression | group | BEFREE | Expression of FOXM1 in KrasG12D transgenic mice increased the mucinous phenotype in KrasG12D-driven lung tumors. | 29267283 | 2017 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Conditional deletion of Foxm1 from Kras(G12D)-expressing respiratory epithelium prevented the initiation of lung tumors in vivo. | 24213573 | 2014 | ||||
|
0.370 | Biomarker | group | CTD_human | Aberrant overexpression of FOXM1 transcription factor plays a critical role in lung carcinogenesis induced by low doses of arsenic. | 23255470 | 2014 | ||||
|
0.370 | AlteredExpression | group | BEFREE | In patients with lung cancer, evaluation of MnSOD expression in lung tumors by immunohistochemistry indicated a positive correlation between FoxM1 and MMP2 mRNA expressions. | 23271813 | 2013 | ||||
|
0.370 | Biomarker | group | BEFREE | Increased activity of Foxm1 altered lung sacculation, induced proliferation in the respiratory epithelium and accelerated lung tumor growth, indicating that precise regulation of Foxm1 is critical for normal lung morphogenesis and development of lung cancer. | 20816795 | 2010 | ||||
|
0.370 | Biomarker | group | BEFREE | Lung tumors were induced in Rosa26-Foxm1 mice using the 3-methylcholanthrene (MCA)/butylated hydroxytoluene (BHT) lung tumor initiation/promotion protocol. | 18345025 | 2008 | ||||
|
0.370 | Biomarker | group | BEFREE | To determine the role of Foxm1 during the development of mouse lung tumors, we used IFN-inducible Mx-Cre recombinase transgene to delete mouse Foxm1 fl/fl-targeted allele before inducing lung tumors with urethane. | 16489016 | 2006 | ||||
|
0.370 | Biomarker | group | CTD_human | We show that Mx-Cre Foxm1-/- mice exhibit diminished proliferation of lung tumor cells causing a significant reduction in number and size of lung adenomas. | 16489016 | 2006 |