Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 AlteredExpression group BEFREE PD-L1 expression appeared to be highly positive in both lung tumor cells and, particularly MDSCs. 30771521 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 Biomarker group BEFREE Correction: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy. 31235866 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 GeneticVariation group BEFREE Compared with 212 EGFR wild-type lung cancers, outcomes with programmed cell death 1 or programmed death-ligand 1 (PD-(L)1) blockade were worse in patients with lung tumors harboring alterations in exon 19 of EGFR (EGFRΔ19) but similar for EGFRL858R lung tumors. 31086949 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 AlteredExpression group BEFREE This study aimed to investigate the role of EZH2 in PD-L1 expression and in the progression of lung tumors. 31331645 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 Biomarker group BEFREE Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy. 30318514 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 AlteredExpression group BEFREE Epidermal growth factor receptor (EGFR) activation was reported to upregulate programmed death-ligand 1 (PD-L1) expression in lung cancer cells and subsequently contribute to immune escape, indicating its critical role in EGFR-driven lung tumors. 30766753 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 GeneticVariation group BEFREE Image analysis accurately enumerated CD8+ TILs in PD-L1+ regions of lung tumors using the dual assay and also measured elongate CD8+ lymphocytes which constituted a fraction of overall TILs. 29510739 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 Biomarker group BEFREE Furthermore, 0.3% GTE in drinking water reduced the average number of tumors per mouse from 4.1 ± 0.5 to 2.6 ± 0.4 and the percentage of PD-L1 positive cells from 9.6% to 2.9%, a decrease of 70%, in lung tumors of A/J mice given a single intraperitoneal injection of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). 30126206 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 AlteredExpression group BEFREE Statistically significant differences in M1 and M2 macrophage infiltration were observed in AAs (<i>P</i> < 0.05); however, <i>PD-L1, PD-L2</i> expression was similar between both.<b>Conclusions:</b> Comparative transcriptomic profiling revealed clear differences in lung tumor biology between AAs and EAs. 29196495 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 AlteredExpression group BEFREE Increased PD-L1 expression and IL-6 secretion characterize human lung tumor-derived perivascular-like cells that promote vascular leakage in a perfusable microvasculature model. 28878242 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 Biomarker group BEFREE Anti-PD-1/PD-L1 therapy inhibited CMT167 orthotopic lung tumors by 95%. 28819064 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 Biomarker group CTD_human Autophagy inhibition upregulates CD4+ tumor infiltrating lymphocyte expression via miR-155 regulation and TRAIL activation. 27692344 2016
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 AlteredExpression group BEFREE We found that lung tumors containing ALK rearrangements induced an immunosuppressive microenvironment, regulating the expression of PD-L1 on the surface of lung tumor cells. 26419961 2015
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 Biomarker group BEFREE We show that autochthonous EGFR-driven lung tumors inhibit antitumor immunity by activating the PD-1/PD-L1 pathway to suppress T-cell function and increase levels of proinflammatory cytokines. 24078774 2013
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 Biomarker group LHGDN B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. 15297412 2004