Gene: MDM2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 AlteredExpression group BEFREE Taken together, GPRC5A deficiency contributes to dysregulated MDM2 via activated EGFR signaling, which promotes lung tumor development. 29992578 2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 Biomarker group BEFREE Consistent observations in the correlation of DDX3 loss with MDM2, Slug and E-cadherin were seen in lung tumors from lung cancer patients. 23584477 2014
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 AlteredExpression group BEFREE In the present study, we examined MDM2 transcriptional activity and messenger RNA (mRNA) expression in lung tumors with respect to MDM2 SNP309 genotypes and p53 mutation status, and the effects of MDM2 SNP309 genotypes and p53 mutation status on lung cancer prognosis. 19941079 2010
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 Biomarker group LHGDN Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk. 17957785 2008
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 Biomarker group LHGDN EGFR, TTF-1 and Mdm2 expression in stage III non-small cell lung cancer: a positive association. 18355939 2008
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 GeneticVariation group LHGDN Combined effects of p73 and MDM2 polymorphisms on the risk of lung cancer. 17013834 2007
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 GeneticVariation group LHGDN MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer. 17538168 2007
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 Biomarker group LHGDN P53 and MDM2 isoforms in blood from lung cancer patients. 17620186 2007
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 GeneticVariation group LHGDN Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population. 16152608 2006
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 GeneticVariation group LHGDN Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. 16287156 2006
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 GeneticVariation group LHGDN Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer. 16496380 2006
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 Biomarker group LHGDN Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines. 15714438 2005
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 AlteredExpression group BEFREE Interestingly, a highly significant inverse relationship was detected between p14(ARF) loss and Mdm2 overexpression either in NSCLC (P=0.0089) or in NE lung tumors (P<0.0001). 11965548 2002
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 AlteredExpression group BEFREE Using immunohistochemistry to screen a panel of human tumors for HDM2 overproduction, we detected high levels of HDM2 in the cytoplasm in 25% of lung tumors as opposed to its normal localization in the nucleus. 11494132 2001
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 AlteredExpression group BEFREE By immunohistochemistry, 33 and 42 of 81 patients with p53 (40.7%) and MDM2 (51.5%) protein expression were found in lung tumor specimens, respectively. 10861503 2000
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.100 Biomarker group BEFREE This may indicate that the mdm2 gene is preferentially altered in this particular subtype of lung tumors. 7551299 1995