Gene: PTGS2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 Biomarker group BEFREE Accordingly, EGFR and COX-2/TNF-α activation/induction is expected to play important roles in MGL deficiency-driven lung tumors. 29348400 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 Biomarker group BEFREE Our results indicate that HSPA12B stimulates lung tumor growth via a Cox-2-dependent mechanism. 25909170 2015
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group BEFREE This shows that COX-2 activity is present during lung tumor development in a high HGF environment. 25057941 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group BEFREE Together, these results support the idea that increased expression of the COX-2 product PGE(2) in the lung tumor microenvironment may initiate a mitogenic signaling cascade composed of EP4, betaArrestin1, and c-Src which mediates cancer cell migration. 20353998 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group BEFREE We used COX-2 transcriptional restriction, in combination with transductional Ad hepatic untargeting and tumor retargeting by a bispecific adapter, sCARhMFE, composed of sCAR [the coxsackie/Ad receptor (CAR) ectodomain] and MFE-23 (a single-chain anti-CEA antibody), to untarget liver after i.v. administration of Ad vectors expressing firefly luciferase and to retarget virus to hepatic colorectal tumor xenografts and non-small cell lung tumor xenografts. 19147569 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN COX-2/EGFR expression and survival among women with adenocarcinoma of the lung. 18453539 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. 18496814 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 Biomarker group LHGDN MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer. 17851225 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group BEFREE These results suggest that Ang-(1-7) may decrease COX-2 activity and proinflammatory prostaglandins to inhibit lung tumor growth. 17363603 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN Specific components of prostanoid-signaling pathways are present in non-small cell lung cancer cells. 17611676 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. 16820889 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results. 16786043 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. 15704107 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer. 16278387 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 GeneticVariation group LHGDN A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population. 15777967 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. 15870920 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 Biomarker group LHGDN Chemoprevention in lung cancer. 15375805 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 GeneticVariation group LHGDN Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. 14604894 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 Biomarker group LHGDN COX-2-dependent stabilization of survivin in non-small cell lung cancer. 14597555 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. 12789263 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 Biomarker group BEFREE Our findings highlight a novel mechanism contributing to maintenance of elevated COX-2 and PGE(2) in the lung tumor environment. 12591723 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN Our findings highlight a novel mechanism contributing to maintenance of elevated COX-2 and PGE(2) in the lung tumor environment. 12591723 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 AlteredExpression group LHGDN Increased expression of COX-2 in the development of human lung cancers. 12086404 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.100 Biomarker group LHGDN Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. 12393872 2002