Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Suppression of Murine Lupus by CD4+ and CD8+ Treg Cells Induced by T Cell-Targeted Nanoparticles Loaded With Interleukin-2 and Transforming Growth Factor β. 30407752 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE However, the low PKC levels in summer can still decrease further the low production of IL-2 in T cells of lupus patients augmenting the existing AP-1 defects. 30715676 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE IL233 is more potent than IL-2 and IL-33 either singly or in combination in the treatment of lupus GN. 31103267 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus. 28646040 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. 23019580 2012
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE Moreover, our results also showed that IFN-γ and IL-2 expression was enhanced in TGP-treated lupus CD4(+) T cells. 22406048 2012
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus. 22942433 2012
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE The expression of miR-31 was significantly decreased in lupus T cells, and this was positively correlated with the expression of IL-2. 22736314 2012
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Our findings establish the genetic association between lupus and IL2/IL21 with a genome-wide level of significance. 21425124 2011
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Furthermore, MRL-lpr/lpr mice injected with LiCl or with arginine-rich peptide restored the IL-2 production and reduced the manifestations of lupus. 20506162 2010
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Defective in vitro IL-2 production in lupus is an early but secondary event paralleling disease activity: evidence from the murine parent-into-F1 model supports staging of IL-2 defects in human lupus. 20001649 2010
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production. 11390516 2001