| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | AlteredExpression | disease | BEFREE | MeCP2 protein levels within the TNFSF7 promoter decreased in patients with active lupus. | 21865261 | 2011 | ||||
|
0.090 | PosttranslationalModification | disease | BEFREE | Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells. | 20223637 | 2010 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1. | 21192791 | 2010 | ||||
|
0.090 | Biomarker | disease | BEFREE | T cell DNA methylation levels decline with age, activating genes such as KIR and TNFSF7 (CD70), implicated in lupus-like autoimmunity and acute coronary syndromes. | 20035856 | 2010 | ||||
|
0.090 | Biomarker | disease | BEFREE | We show that decreased ERK pathway signaling in T cells results in decreased expression of DNA methyltransferase 1 and overexpression of the methylation-sensitive genes CD11a and CD70, similar to T cells in human lupus. | 18523434 | 2008 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Pharmacologic inhibition of PKCdelta or transfection with a dominant negative PKCdelta mutant caused demethylation of the TNFSF7 (CD70) promoter and CD70 overexpression similar to lupus and hydralazine-treated T cells. | 17911642 | 2007 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Controls included TNFSF7, a methylation-sensitive autosomal B cell costimulatory molecule known to be demethylated and overexpressed in lupus. | 17947713 | 2007 | ||||
|
0.090 | Biomarker | disease | BEFREE | CD70 (TNFSF7) is a B cell costimulatory molecule overexpressed on CD4(+) lupus T cells as well as procainamide and hydralazine treated T cells, and contributes to excessive B cell stimulation in vitro and in lupus. | 15879118 | 2005 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. | 15188362 | 2004 |