Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 GeneticVariation disease BEFREE Enhanced ABC formation in SWEF-deficient mice was controlled by the cytokine IL-21 and IRF5, whose variants are strongly associated with lupus. 29483597 2018
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 GeneticVariation disease BEFREE Although we could not demonstrate susceptibility toward lupus in the presence of IRF5 rs2004640 (G/T) polymorphism, further exploration of the genetic variability of IRF5 may help uncover its pathogenic role in Indian SLE patients. 30168487 2018
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 GeneticVariation disease BEFREE Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects. 29867973 2018
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE <i>IRF5</i> genetic risk has been widely replicated in systemic lupus erythematosus (SLE), and loss of <i>Irf5</i> ameliorates disease in murine lupus models, in part, through the lack of pathogenic autoantibody secretion. 29367853 2017
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 GeneticVariation disease BEFREE Association of interferon regulatory factor 5 (IRF5) markers with an increased risk of lupus and overlapping autoimmunity in a Kuwaiti population. 24697591 2015
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA, and KIF5A. 26092158 2015
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE A redundant epistatic interaction between IRF5 and STAT4 of the type I interferon pathway in susceptibility to lupus and rheumatoid arthritis. 24014567 2013
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Interferon regulatory factor 5 and autoimmune lupus. 23883595 2013
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Taken together, these findings demonstrate an intrinsic role for IRF5 in the response of monocytes to pristane and their recruitment to the primary site of inflammation that is thought to trigger lupus onset in this experimental model of SLE. 22933628 2012
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Collectively, these data indicate that altered production of IFN-I and other cytokines in IRF5(-/-) mice prevents pristane from inducing lupus pathology by broadly affecting T and B lymphocyte activation/differentiation. 22422888 2012
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 GeneticVariation disease BEFREE Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively). 21952918 2012
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE However, it remains unclear how IRF5 and Blimp-1 (a transcriptional target of IRF5) contribute to lupus susceptibility. 22116829 2012
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Our results show that IRF5 is a crucial driver of lupus development in mice, and indicate that IRF5 may be an attractive new target for therapeutic intervention to control disease in SLE patients. 21305501 2011
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 AlteredExpression disease BEFREE We found that the expression levels of interferon regulatory factor 5 (IRF5), a lupus susceptibility factor, depend on gender of mice. 20802013 2010
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 GeneticVariation disease BEFREE A meta-analysis of the genetic association of the 16 SNPs across populations showed that TNFSF4, STAT4, ITGAM, and IRF5 were associated with lupus in a Hispanic Mestizo cohort enriched for European and Amerindian ancestry. 20848568 2010
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Interferon regulatory factors coordinate the expression of type I IFNs, and the IRF5 gene has been identified as a susceptibility gene of systemic lupus and Sjögren's syndrome. 19116937 2009
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Interestingly, recent studies have not found association of IRF5 with the other autoimmune diseases, such as rheumatoid arthritis or psoriasis, suggesting the unique role for IRF5 in the development of lupus. 18075793 2007
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 GeneticVariation disease BEFREE Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. 17412832 2007