Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Patients with isolated anti-Ro52 had a wider variety of diseases associated, but among auto-immune diseases they were more prone to inflammatory myositis (OR 10.5 [1.4-81.7], <i>p</i> = 0.02) and inflammatory rheumatism (OR 4.6 [1.6-13.8], <i>p</i> = 0.006) in contrast to systemic lupus (OR 0.2 [0.1-0.3], <i>p</i> < 10<sup>-4</sup>) or primary Sjögren's syndrome (OR 0.1 [0.06-0.2], <i>p</i> < 10<sup>-4</sup>). 30915082 2019
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Men with lupus had less anti-SSA (21.1 vs 48.1%) and anti-Ro52 (10.5 vs 44.3%) antibodies when compared to women and none of the male patients had anti-SSB antibodies. 29265023 2017
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 AlteredExpression disease BEFREE Up-regulated expression of Ro52/tripartite motif-containing protein 21 (TRIM21), Ro60/TROVE domain family, member 2 (TROVE2) and lupus LA protein/Sjögren's syndrome antigen B (La/SSB) autoantigens has been described in the salivary gland epithelial cells (SGEC) of patients with Sjögren's syndrome (SS). 25098814 2014
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 AlteredExpression disease BEFREE Of the two autoantibodies studied, anti-Ro/anti-SSA levels in borderline lupus patients appeared as an important parameter for monitoring/diagnosis of lupus patients. 23832290 2013
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Autoantibodies to Ro52 are present in patients with lupus and Sjögren's syndrome, but it is not known if these autoantibodies affect the function of Ro52. 21862588 2011
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. 19635858 2009
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Genetic knock out of 60kD Ro (or SSA), a common lupus autoantigen, induces lupus. 14698275 2004
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Although this remains among the most attractive of hypotheses for the explanation of Ro/SS-A antibody-associated forms of LESSD such as SCLE and neonatal LE, it does not address the pathogenesis of other forms of LESSD such as DLE, which are not associated with high-level Ro/SS-A antibody production or other known autoantibody specificities (low-level Ro/SS-A autoantibody production has been noted recently in DLE patients (155)). 8628749 1996
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE The results of this study indicate that the antigenic determinants on Ro52 are different for autoantibodies produced by lupus patients compared with those of SS patients. 7693382 1993
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE Neonatal lupus erythematosus (NLE) is a distinct subset of lupus characterized by cutaneous findings (50%), cardiac conduction defects (50%), and autoantibodies to Ro (SS-A) antigen. 1444503 1992
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.100 Biomarker disease BEFREE These data demonstrate that anti-Ro(SS-A)/La(SS-B) positive Sjogren's/lupus overlap patients and neonatal lupus syndrome mothers are immunogenetically closely related to each other and appear to be more closely related to both primary Sjogren's syndrome and subacute lupus erythematosus, than to classical systemic lupus erythematosus. 2584740 1989