Gene: BLK ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 CausalMutation disease CLINVAR
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease BEFREE BLK pathway-associated rs13277113 GA genotype is more frequent in SLE patients and associated with low gene expression and increased flares. 27864698 2017
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 SusceptibilityMutation disease ORPHANET Advances in lupus genetics. 23917156 2013
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 Biomarker disease BEFREE BANK1 and BLK belong to the pleiotropic autoimmune genes; recently, epistasis between BANK1 and BLK was detected in systemic lupus erythematosus. 23646104 2013
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease BEFREE BANK1, BLK and SNP in 1q25.1 region were associated with not only SLE but also APS in Japanese population. 25524556 2015
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease BEFREE CFH (P=8.41 × 10(-6)), HLA-DRA (P=4.91 × 10(-6)), HLA-DRB1 (P=9.46 × 10(-9)), PXK (P=3.62 × 10(-4)), BLK (P=9.32 × 10(-3)), and UBE2L3 (P=4.07 × 10(-3)) were identified as shared genes between IgAN and SLE. 24458077 2014
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 AlteredExpression disease BEFREE Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels. 25972485 2015
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease BEFREE Epistatic interactions between BANK1 and BLK polymorphisms associated with SLE were observed in a discovery set of 279 patients and 515 controls from northern Europe. 21978998 2012
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease BEFREE Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus. 31101814 2019
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 Biomarker disease BEFREE Gene-gene interaction of ATG5, ATG7, BLK and BANK1 in systemic lupus erythematosus. 26420661 2016
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease GWASCAT Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. 19165918 2008
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease GWASDB Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. 19165918 2008
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 SusceptibilityMutation disease ORPHANET Genetics and epigenetics of systemic lupus erythematosus. 23943494 2013
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease GWASDB Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. 18204446 2008
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 Biomarker disease CTD_human Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. 19838193 2009
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease GWASDB Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. 19838193 2009
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease GWASCAT Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis. 23053960 2012
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease GWASDB Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis. 23053960 2012
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 SusceptibilityMutation disease ORPHANET Genotyping of 1163 European SLE patients and 1482 controls and imputation were performed covering the BLK gene with 158 single-nucleotide polymorphisms. 22696686 2012
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease BEFREE However, genetic association studies that have examined the association between BLK gene variants and SLE have produced conflicting results. 21152986 2011
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease GWASCAT Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. 26663301 2016
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 Biomarker disease BEFREE In a combined analysis of 1596 SLE patients and 2540 controls for selected 22 candidate SNP, STAT4 and BLK as positive controls showed a strong association with SLE (FDR p=9.85×10(-13) and 2.28×10(-8), respectively). 23740238 2014
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease BEFREE In this report, we used a trans-population mapping and sequencing strategy to identify a common variant (rs922483) in the proximal BLK promoter and a tri-allelic variant (rs1382568) in the upstream alternative BLK promoter as putative causal variants for association with systemic lupus erythematosus. 24702955 2014
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 GeneticVariation disease GWASDB Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.700 AlteredExpression disease BEFREE Methylation site cg09528494 and mRNA expression of BLK were causally associated with SLE. 31670388 2020