Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE This allosteric regulation by an SNP provides an intrinsic molecular mechanism for the functional loss of FcγRIIB-I232T in SLE patients. 31343409 2019
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE We show that a SNP in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to SLE in both Caucasians and Southeast Asians. 20385827 2010
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE In conclusion, the mutual interactions between HP and lupus manifestations of FcγRIIb-/-mice were demonstrated in this study. 30034379 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE FcγRIIb-I232T is a hypofunctional polymorphism associated with lupus susceptibility in humans, an autoimmune disease linked to diminished deletion of autoreactive B cells. 29774664 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE In the presence of the Yaa lupus-susceptibility locus, FcγRIIB(B6)(-/-) mice do develop lethal lupus, confirming that FcγRIIB deficiency only amplifies spontaneous autoimmunity determined by other loci. 21724994 2011
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE CD19<sup>Cre</sup><i>Yaa</i> mice developed milder lupus than B6.FcγRIIb<sup>-/-</sup><i>Yaa</i> mice, indicating that FcγRIIb deficiency on B cells is not sufficient for the development of severe disease. 30373853 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Skewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients. 8849356 1995
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE To determine whether 7 candidate genes, including tumor necrosis factor receptor II, bcl-2, CTLA-4, interleukin-10 (IL-10), CD19, Fcy receptor type IIA (CD32), and IL-1 receptor antagonist, may contribute to susceptibility to systemic lupus erythematosus (SLE) in the Italian population. 10643707 2000
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Selective silencing of double-stranded DNA-specific B cells in animals with spontaneous lupus has been achieved previously by the administration of a chimeric antibody molecule that cross-links their DNA-reactive B cell immunoglobulin receptors with inhibitory FcγIIb (CD32) receptors. 23808414 2013
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Given that the murine lupus susceptibility locus Nba2 includes the IFN-regulated genes Ifi202 (encoding for the p202 protein), Aim2 (encoding for the Aim2 protein), and Fcgr2b (encoding for the FcγRIIB receptor), we investigated whether the IRF5/Blimp-1 axis could regulate the expression of these genes. 22116829 2012
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Thus CN of FCGR3B, which controls IC responses and uptake by neutrophils, and variations in FCGR2B, which controls factors such as antibody production and macrophage activation, are important in SLE pathogenesis. 20508037 2010
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Mice that are prone to SLE because of a deficiency in FcγRIIB or overexpression of Toll-like receptor 7 are protected from death caused by cerebral malaria. 21187399 2011
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Using the two Asian cohorts, significant association of FCGR2B-232Thr/Thr with SLE was observed only in the presence of CD72-*1/*1 genotype (OR 4.63, 95% CI 1.47-14.6, P=0.009 versus FCGR2B-232Ile/Ile plus CD72-*2/*2). 15459183 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE These results suggest that an expression variant of FCGR2B is a risk factor for human lupus and implicate FCGR2B in disease pathogenesis. 15153543 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Interestingly, recent studies involving the generation of Nba2 subcongenic mouse lines and generation of mice deficient for the Fcgr2b or Aim2 gene within the interval have provided evidence that epistatic interactions among the Nba2 genes contribute to increased lupus susceptibility. 22841963 2012
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Combined analysis of 4 groups of Asian patients strongly supported the association of the FCGR2B Thr187 allele with the lupus phenotype (P = 0.000159). 17133600 2006
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus. 22647731 2012
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Because mice deficient in either Sirt1 or FcγRIIB develop lupus-like diseases, we investigated whether resveratrol can alleviate lupus through FcγRIIB. 28960214 2017
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE We investigated the influence of spontaneous gut leakage upon polymicrobial sepsis in a lupus model with Fc gamma receptor IIb-deficient (FcGRIIb-/-) mice aged 8 and 40 weeks, as representing asymptomatic and symptomatic lupus, respectively. 29393221 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Interestingly, the presence of the haplotype significantly decreased the risk of SLE conferred by FCGR2B-232Thr in an epistatic manner. 16946996 2006
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Our study demonstrated an association of FcγRIIB polymorphisms with SLE and lupus nephritis and a lack of association of FcγRIIA polymorphisms with SLE in the Egyptian patients. 24366619 2014
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE This inhibitory function of FcγRIIB in impairing the spatial-temporal colocalization of BCR and CD19 microclusters in the B cell immunological synapse may help explain the hyper-reactive features of systemic lupus erythematosus patient B cells in reported studies. 24790152 2014
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Interestingly, while these alleles had a tendency of positive LD in the controls, FCGR2B-232T was in positive association with FCGR3A-176V in SLE, suggesting that these two alleles were associated with SLE in an independent manner. 14651519 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE We previously demonstrated significant association of the polymorphism of the CD72 gene with susceptibility to human systemic lupus erythematosus (SLE) in individuals carrying a SLE-susceptible FCGR2B genotype (FCGR2B-232Thr/Thr). 23268649 2012
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Indeed, recent epidemiological studies revealed that a non-synonymous single nucleotide polymorphism (rs1050501) within the TM domain of FcγRIIB, responsible for the I232T substitution, is associated with the susceptibility to systemic lupus erythematosus (SLE). 29497990 2018