Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE A single-nucleotide polymorphism in the transmembrane (TM) domain of FcγRIIB, FcγRIIB-T232, is associated with lupus. 27799621 2016
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE However, 6- and 10-month-old FcγRIIB<sup>-/-</sup> males that developed an SLE-like phenotype were osteopenic and FcγRIIB deletion resulted in decreased cancellous bone volume. 31758072 2019
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE The inflammation intensity in the liver decreased with IgG depletion and the lupus IgG-induced liver inflammation in FcγRIII-deficient mice was comparatively low; while, inflammation was increased in FcγRIIb-deficient mice. 29988500 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE We conclude that FCGR3B deletion juxtaposes the 5'-regulatory sequences of FCGR2C with the coding sequence of FCGR2B, creating a chimeric gene that results in an ectopic accumulation of FcγRIIb on NK cells and provides an explanation for SLE risk associated with reduced FCGR3B gene copy number. 23261299 2013
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE To examine the possibility that another susceptibility gene of primary significance exists within the FcgammaR region, we screened for polymorphisms of the human FCGR2B gene, and examined whether these polymorphisms are associated with SLE. 12115230 2002
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE In the present study, we have investigated nephritis development and progression in FcγRIIB-/-yaa mice to find shared features with NZB/NZW F1 lupus prone mice and human disease. 29190833 2017
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE We have identified a polymorphism FCGR2B c.695T>C that results in the non-conservative replacement of 232Ile at the transmembrane helix to Thr and demonstrated the association of the polymorphism with susceptibility to systemic lupus erythematosus (SLE) in Asians. 16115811 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE These results indicate that FCGR2B is a susceptibility gene to SLE in the context of a genetic background, both in humans and mice. 16227149 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE In FCGR2B encoding an inhibitory receptor expressed in B cells, monocytes and dendritic cells, a polymorphism within the transmembrane region, Ile232Thr, was identified and found to be associated with susceptibility to SLE in three Asian populations. 17305544 2007
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE In humans, a SLE-associated polymorphism (rs1050501) results in a dysfunctional FcγRIIB(T232) receptor. 25475856 2014
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE In contrast, 3-month-old FcγRIIB<sup>-/-</sup> mice did not develop the active SLE disease. 30116830 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Mannose binding lectin and FcgammaRIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients. 11561111 2001
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Recently, among other mutations, rare null-alleles for the deoxyribonuclease 1 like 3 (<i>DNASE1L3</i>) and the Fc gamma receptor IIB (<i>FCGR2B</i>) have been described in SLE patients and genetic mouse models. 30026744 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE A single nucleotide polymorphism in human FcγRIIB (rs1050501) results in profound receptor dysfunction and is associated with systemic lupus erythematosus. 25022320 2014
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Here, we report about a spurious (reitered) association between FCGR2B genetic polymorphisms and systemic lupus erythematosus. 19005878 2009
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 AlteredExpression disease BEFREE Thus, amplification of the FcγRIIb inhibitory pathway in activated B cells may represent a novel B cell-targeted immunosuppressive therapeutic approach for SLE and other autoimmune diseases that should avoid the complications associated with B cell depletion. 21357255 2011
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE The role of activating protein 1 in the transcriptional regulation of the human FCGR2B promoter mediated by the -343 G -> C polymorphism associated with systemic lupus erythematosus. 17130130 2007
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Furthermore, FcγRIIB rs12117530 polymorphism (T allele) may be an important risk factor in SLE. 26084639 2015
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 AlteredExpression disease BEFREE These findings suggest that genetic defects may lead to deregulated expression of the FCGR2B gene in -343 C/C homozygous subjects, and may play a role in the pathogenesis of human SLE. 15895258 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease CTD_human
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN These results indicate that FCGR2B is a susceptibility gene to SLE in the context of a genetic background, both in humans and mice. 16227149 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 AlteredExpression disease LHGDN Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE. 16923849 2006
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN We have identified a polymorphism FCGR2B c.695T>C that results in the non-conservative replacement of 232Ile at the transmembrane helix to Thr and demonstrated the association of the polymorphism with susceptibility to systemic lupus erythematosus (SLE) in Asians. 16115811 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN Here, we report about a spurious (reitered) association between FCGR2B genetic polymorphisms and systemic lupus erythematosus. 19005878 2009
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN Using the two Asian cohorts, significant association of FCGR2B-232Thr/Thr with SLE was observed only in the presence of CD72-*1/*1 genotype (OR 4.63, 95% CI 1.47-14.6, P=0.009 versus FCGR2B-232Ile/Ile plus CD72-*2/*2). 15459183 2004