Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE In the presence of the Yaa lupus-susceptibility locus, FcγRIIB(B6)(-/-) mice do develop lethal lupus, confirming that FcγRIIB deficiency only amplifies spontaneous autoimmunity determined by other loci. 21724994 2011
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Mice that are prone to SLE because of a deficiency in FcγRIIB or overexpression of Toll-like receptor 7 are protected from death caused by cerebral malaria. 21187399 2011
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease MGD A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. 21159799 2011
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 AlteredExpression disease BEFREE Thus, amplification of the FcγRIIb inhibitory pathway in activated B cells may represent a novel B cell-targeted immunosuppressive therapeutic approach for SLE and other autoimmune diseases that should avoid the complications associated with B cell depletion. 21357255 2011
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE We show that a SNP in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to SLE in both Caucasians and Southeast Asians. 20385827 2010
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Thus CN of FCGR3B, which controls IC responses and uptake by neutrophils, and variations in FCGR2B, which controls factors such as antibody production and macrophage activation, are important in SLE pathogenesis. 20508037 2010
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 SusceptibilityMutation disease ORPHANET We show that a SNP in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to SLE in both Caucasians and Southeast Asians. 20385827 2010
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN Here, we report about a spurious (reitered) association between FCGR2B genetic polymorphisms and systemic lupus erythematosus. 19005878 2009
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Here, we report about a spurious (reitered) association between FCGR2B genetic polymorphisms and systemic lupus erythematosus. 19005878 2009
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN Genetic susceptibility and haplotype analysis between Fcgamma receptor IIB and IIIA gene with systemic lupus erythematosus in Chinese population. 18625651 2008
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE In FCGR2B encoding an inhibitory receptor expressed in B cells, monocytes and dendritic cells, a polymorphism within the transmembrane region, Ile232Thr, was identified and found to be associated with susceptibility to SLE in three Asian populations. 17305544 2007
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN This mechanism could be responsible for the decreased expression of FcgammaRIIb associated with the -343 C/C homozygous FCGR2B genotype in lupus patients. 17130130 2007
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE The role of activating protein 1 in the transcriptional regulation of the human FCGR2B promoter mediated by the -343 G -> C polymorphism associated with systemic lupus erythematosus. 17130130 2007
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 AlteredExpression disease LHGDN Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE. 16923849 2006
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Combined analysis of 4 groups of Asian patients strongly supported the association of the FCGR2B Thr187 allele with the lupus phenotype (P = 0.000159). 17133600 2006
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Interestingly, the presence of the haplotype significantly decreased the risk of SLE conferred by FCGR2B-232Thr in an epistatic manner. 16946996 2006
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN These results indicate that FCGR2B is a susceptibility gene to SLE in the context of a genetic background, both in humans and mice. 16227149 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN We have identified a polymorphism FCGR2B c.695T>C that results in the non-conservative replacement of 232Ile at the transmembrane helix to Thr and demonstrated the association of the polymorphism with susceptibility to systemic lupus erythematosus (SLE) in Asians. 16115811 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE We have identified a polymorphism FCGR2B c.695T>C that results in the non-conservative replacement of 232Ile at the transmembrane helix to Thr and demonstrated the association of the polymorphism with susceptibility to systemic lupus erythematosus (SLE) in Asians. 16115811 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE These results indicate that FCGR2B is a susceptibility gene to SLE in the context of a genetic background, both in humans and mice. 16227149 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 AlteredExpression disease BEFREE These findings suggest that genetic defects may lead to deregulated expression of the FCGR2B gene in -343 C/C homozygous subjects, and may play a role in the pathogenesis of human SLE. 15895258 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Using the two Asian cohorts, significant association of FCGR2B-232Thr/Thr with SLE was observed only in the presence of CD72-*1/*1 genotype (OR 4.63, 95% CI 1.47-14.6, P=0.009 versus FCGR2B-232Ile/Ile plus CD72-*2/*2). 15459183 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE These results suggest that an expression variant of FCGR2B is a risk factor for human lupus and implicate FCGR2B in disease pathogenesis. 15153543 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Interestingly, while these alleles had a tendency of positive LD in the controls, FCGR2B-232T was in positive association with FCGR3A-176V in SLE, suggesting that these two alleles were associated with SLE in an independent manner. 14651519 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN Using the two Asian cohorts, significant association of FCGR2B-232Thr/Thr with SLE was observed only in the presence of CD72-*1/*1 genotype (OR 4.63, 95% CI 1.47-14.6, P=0.009 versus FCGR2B-232Ile/Ile plus CD72-*2/*2). 15459183 2004