Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Interestingly, recent studies involving the generation of Nba2 subcongenic mouse lines and generation of mice deficient for the Fcgr2b or Aim2 gene within the interval have provided evidence that epistatic interactions among the Nba2 genes contribute to increased lupus susceptibility. 22841963 2012
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Interestingly, the presence of the haplotype significantly decreased the risk of SLE conferred by FCGR2B-232Thr in an epistatic manner. 16946996 2006
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Interestingly, while these alleles had a tendency of positive LD in the controls, FCGR2B-232T was in positive association with FCGR3A-176V in SLE, suggesting that these two alleles were associated with SLE in an independent manner. 14651519 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Mannose binding lectin and FcgammaRIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients. 11561111 2001
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Mice that are prone to SLE because of a deficiency in FcγRIIB or overexpression of Toll-like receptor 7 are protected from death caused by cerebral malaria. 21187399 2011
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Our study demonstrated an association of FcγRIIB polymorphisms with SLE and lupus nephritis and a lack of association of FcγRIIA polymorphisms with SLE in the Egyptian patients. 24366619 2014
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Recently, among other mutations, rare null-alleles for the deoxyribonuclease 1 like 3 (<i>DNASE1L3</i>) and the Fc gamma receptor IIB (<i>FCGR2B</i>) have been described in SLE patients and genetic mouse models. 30026744 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 AlteredExpression disease LHGDN Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE. 16923849 2006
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Selective silencing of double-stranded DNA-specific B cells in animals with spontaneous lupus has been achieved previously by the administration of a chimeric antibody molecule that cross-links their DNA-reactive B cell immunoglobulin receptors with inhibitory FcγIIb (CD32) receptors. 23808414 2013
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Skewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients. 8849356 1995
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease MGD Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. 10981970 2000
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE The inflammation intensity in the liver decreased with IgG depletion and the lupus IgG-induced liver inflammation in FcγRIII-deficient mice was comparatively low; while, inflammation was increased in FcγRIIb-deficient mice. 29988500 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE The role of activating protein 1 in the transcriptional regulation of the human FCGR2B promoter mediated by the -343 G -> C polymorphism associated with systemic lupus erythematosus. 17130130 2007
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 AlteredExpression disease BEFREE These findings suggest that genetic defects may lead to deregulated expression of the FCGR2B gene in -343 C/C homozygous subjects, and may play a role in the pathogenesis of human SLE. 15895258 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN These results indicate that FCGR2B is a susceptibility gene to SLE in the context of a genetic background, both in humans and mice. 16227149 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE These results indicate that FCGR2B is a susceptibility gene to SLE in the context of a genetic background, both in humans and mice. 16227149 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE These results suggest that an expression variant of FCGR2B is a risk factor for human lupus and implicate FCGR2B in disease pathogenesis. 15153543 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE This allosteric regulation by an SNP provides an intrinsic molecular mechanism for the functional loss of FcγRIIB-I232T in SLE patients. 31343409 2019
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE This inhibitory function of FcγRIIB in impairing the spatial-temporal colocalization of BCR and CD19 microclusters in the B cell immunological synapse may help explain the hyper-reactive features of systemic lupus erythematosus patient B cells in reported studies. 24790152 2014
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN This mechanism could be responsible for the decreased expression of FcgammaRIIb associated with the -343 C/C homozygous FCGR2B genotype in lupus patients. 17130130 2007
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE Thus CN of FCGR3B, which controls IC responses and uptake by neutrophils, and variations in FCGR2B, which controls factors such as antibody production and macrophage activation, are important in SLE pathogenesis. 20508037 2010
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 AlteredExpression disease BEFREE Thus, amplification of the FcγRIIb inhibitory pathway in activated B cells may represent a novel B cell-targeted immunosuppressive therapeutic approach for SLE and other autoimmune diseases that should avoid the complications associated with B cell depletion. 21357255 2011
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE To determine whether 7 candidate genes, including tumor necrosis factor receptor II, bcl-2, CTLA-4, interleukin-10 (IL-10), CD19, Fcy receptor type IIA (CD32), and IL-1 receptor antagonist, may contribute to susceptibility to systemic lupus erythematosus (SLE) in the Italian population. 10643707 2000
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 SusceptibilityMutation disease ORPHANET To examine the possibility that another susceptibility gene of primary significance exists within the FcgammaR region, we screened for polymorphisms of the human FCGR2B gene, and examined whether these polymorphisms are associated with SLE. 12115230 2002
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE To examine the possibility that another susceptibility gene of primary significance exists within the FcgammaR region, we screened for polymorphisms of the human FCGR2B gene, and examined whether these polymorphisms are associated with SLE. 12115230 2002