Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN Using the two Asian cohorts, significant association of FCGR2B-232Thr/Thr with SLE was observed only in the presence of CD72-*1/*1 genotype (OR 4.63, 95% CI 1.47-14.6, P=0.009 versus FCGR2B-232Ile/Ile plus CD72-*2/*2). 15459183 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE Using the two Asian cohorts, significant association of FCGR2B-232Thr/Thr with SLE was observed only in the presence of CD72-*1/*1 genotype (OR 4.63, 95% CI 1.47-14.6, P=0.009 versus FCGR2B-232Ile/Ile plus CD72-*2/*2). 15459183 2004
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE We conclude that FCGR3B deletion juxtaposes the 5'-regulatory sequences of FCGR2C with the coding sequence of FCGR2B, creating a chimeric gene that results in an ectopic accumulation of FcγRIIb on NK cells and provides an explanation for SLE risk associated with reduced FCGR3B gene copy number. 23261299 2013
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease LHGDN We have identified a polymorphism FCGR2B c.695T>C that results in the non-conservative replacement of 232Ile at the transmembrane helix to Thr and demonstrated the association of the polymorphism with susceptibility to systemic lupus erythematosus (SLE) in Asians. 16115811 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE We have identified a polymorphism FCGR2B c.695T>C that results in the non-conservative replacement of 232Ile at the transmembrane helix to Thr and demonstrated the association of the polymorphism with susceptibility to systemic lupus erythematosus (SLE) in Asians. 16115811 2005
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 Biomarker disease BEFREE We investigated the influence of spontaneous gut leakage upon polymicrobial sepsis in a lupus model with Fc gamma receptor IIb-deficient (FcGRIIb-/-) mice aged 8 and 40 weeks, as representing asymptomatic and symptomatic lupus, respectively. 29393221 2018
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE We previously demonstrated significant association of the polymorphism of the CD72 gene with susceptibility to human systemic lupus erythematosus (SLE) in individuals carrying a SLE-susceptible FCGR2B genotype (FCGR2B-232Thr/Thr). 23268649 2012
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 GeneticVariation disease BEFREE We show that a SNP in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to SLE in both Caucasians and Southeast Asians. 20385827 2010
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.900 SusceptibilityMutation disease ORPHANET We show that a SNP in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to SLE in both Caucasians and Southeast Asians. 20385827 2010