|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The minor allele G and its homozygous genotype GG of HLA-DRB1/HLA-DQA1 rs9271366 significantly increased the SLE susceptibility in Malaysian patients, including those of Malay and Chinese ethnicity (odds ratio (OR) > 1, p < 0.05).
|
23257407 |
2013 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found that 14 SNPs, which were significantly associated with SLE in previous studies, have cis-regulation effects on four eQTL genes (HLA-DQA1, HLA-DQB1, HLA-DQB2, and IRF5) that were also differentially expressed in SLE-related cell groups.
|
23341919 |
2013 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results from conditional analysis and model choice with the use of the Bayesian information criterion show that the best model for SLE association includes both classical loci (HLA-DRB1(∗)03:01, HLA-DRB1(∗)08:01, and HLA-DQA1(∗)01:02) and two SNPs, rs8192591 (in class III and upstream of NOTCH4) and rs2246618 (MICB in class I).
|
23084292 |
2012 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, the established SLE-associated HLA-DRB1*15 signal was refined to an interval encompassing HLA-DRB1 and HLA-DQA1.
|
22233601 |
2012 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
When analysis was limited to male subjects with SLE-associated HLA genes (encoding HLA-DR2 or HLA-DR3), the differences further increased for DRB1 basic groups (OR 7.2, P = 0.01), DRB1 alleles (OR 15.0, P = 0.018), DQA1 6.4 (P = 0.006), and DQB1 (OR 5.7, P = 0.027).
|
16142706 |
2005 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Allele distribution comparison showed in the SLE group a significant increase of HLA-DQA1*0102, DQB1*0402, and DRB1*15; whereas alleles HLA-DQB1*0303 and *0501 were significantly decreased.
|
15603875 |
2004 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To analyse the influence of HLA-DR, DQ and corresponding DQA1 and DQB1 promoter alleles (QAP and QBP) on the anti-Ro alone autoantibody response in systemic lupus erythematosus (SLE).
|
11934968 |
2002 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the DRB1*0301 is the principal class II allele associated with the genetic susceptibility to SLE in Mexican patients and that the presence of a specific haplotype of the homologous chromosome in patients with DRB1*0407-DQA1*03-DQB1*0302 and DRB1*1501-DQA1*0102-DQB1*0602 haplotypes could have an additive effect on the susceptibility to the disease.
|
11476905 |
2001 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found a strong association of the DQA1*0102 (p corr = 0.032, rr = 3.39), DQB1*0501 (p corr = 0.003, rr = 4.55), *0601 (p corr = 0.006, rr = 4.22) and DPB1* 0901(p corr = 0.02, rr = 4.58) with SLE.
|
11699726 |
2001 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This explains the lack of association with the allele alone, and the evident strong association of SLE with the [HLA-DR3-DQA1*0501-DQB1*0201] and [HLA-DR1-DQA1*0101-DQB1*0501] haplotypes.
|
9808402 |
1998 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Total SLE group: the frequency of HLA-DR3 and HLA-DQA1*0501 is significantly increased in this group (pc < 0.005, delta = 0.34 and pc < 0.005, delta = 0.45, respectively) although the highest delta value (delta = 0.87) is obtained when the TAP2*01 alleles are considered.
|
9709177 |
1998 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results support the hypothesis that susceptibility to SLE is influenced by several genes with differing functions: HLA-DQA*0501 may predispose to autoantibody formation while C4A*Q0 impairs immune complex clearance.
|
7728395 |
1995 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
This may suggest that HLA class II molecules themselves and/or an unknown susceptibility gene located near the DQA1 and DRB1 loci are involved in the pathogenesis of SLE.
|
7481564 |
1995 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the DQA1*0501-associated 4.56 kb DQA TaqI fragment and the DRB3*01/03-associated 9.79 kb TaqI fragment were also found to be significantly increased in SLE patients (70.8% vs 29.7%; RR = 5.8, p < 10(-2) for the DQA fragment and 70.8% vs 36.1%; RR = 4.3, p < 0.05 for the DRB3 fragment).
|
7912858 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We concluded that the presence of antibodies against recombinant U1-nRNP proteins was not significantly associated with any HLA DRB1, DQA1 and DQB1 allele in our group of SLE patients.
|
7824837 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
By investigating the DQA1 promoter region in the SLE patients we have detected nine different QAP variants.
|
8406614 |
1993 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
While patients with anti-RNP precipitin showed an increased frequency of the DQw8-associated allele DQB1*0302 (P = 0.02, OR = 3.7) compared with normal controls, as well as an increased frequency of the DQw5-associated alleles DQA1*0101 and DQB1*0501 (P = 0.05, OR = 4.2) compared with lupus patients without anti-Sm or RNP.
|
7678744 |
1993 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Molecular analysis of DQB1 and DQA1 alleles found in American Caucasian and American black SS (or SLE) patients demonstrated high frequencies of DQB1*0201 and DQA1*0501.
|
8340232 |
1993 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
By using the etiologic fraction (delta) as an almost absolute measure of the strongest linkage disequilibrium of an HLA marker to the putative SLE susceptibility locus, it has been found that the strength of association of the HLA marker may be quantified as follows: DQA1*0501 (associated to DR3) or DQB1*0201 (associated to DR3) > non Asp 57 beta DQ/Arg 52 alpha DQ > DR3 > non Asp 57 beta DQ.
|
8101832 |
1993 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The typing results suggest that susceptibility to MCTD is strongly associated with the HLA-DRB1*0401-DRB4*0101-DQA1*03-DQB1*0301 haplotype, and that to SLE is associated with the HLA-DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602 haplotype.
|
8456439 |
1993 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*0301, DQA1*0501, DQB1*0201 was more common in Caucasians and DRB1*1503, DRB5*0101, DQA1*0102, DQB1*0602 in American blacks, regardless of age at SLE onset.
|
8452580 |
1993 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
When compared to the low-risk group (nonDRB1*03 class II heterozygotes), the cases homozygous for DRB1*03,DQA1*0501,DQB1*0201, known to be in linkage disequilibrium with the complement allele C4A*Q0, had the highest relative risk of developing SLE (RR = 16.39, p = 0.0002).
|
1440567 |
1992 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We therefore propose that a DQA1*0201/DQB1*0201-encoded HLA-DQ trans-dimer formed in these heterozygotes might function as a suppressor-inducer molecule that confers resistance against SLE.
|
2063393 |
1991 |