Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 AlteredExpression disease BEFREE IFNα upregulated HLA-DRB1 expression on lupus but not control CD8+ T cells. 30674474 2019
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE The aim of the study was to explore whether TGF-β and IL-6 gene polymorphisms may be associated with SLE and assess the frequency of HLA-DRB1 alleles in Polish systemic lupus erythematosus (SLE) patients. 30943147 2019
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE In this cohort, SNP rs9271366 (tag SNP for HLA-DRB1*15:01) confers the highest risk for SLE among the 13 MHC gene alleles that display association with SLE (p = 8.748E-10; OR = 3.5). 31032751 2019
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Our results confirm the association between TNF and DRB1 polymorphisms and SLE. 29912900 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE This study demonstrated that the presence of HLA-DRB1*15 was a strong factor that predisposed patients to the development of SLE and LN, but did not influence kidney graft survival. 29421495 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Next-generation sequencing analysis of the MHC region (previously suggested to be a hot region in atypical psychosis) using HLA typing (HLA-DRB1) revealed a common vulnerability with SLE (systemic lupus erythematosus) among five patients. 30323194 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE The association of homozygous deletion of C4A and SLE is accompanied by the presence of HLA-DRB1*0301 without a proven pathophysiological mechanism. 29050534 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Case-control studies on HLA-DRB1 and SLE were searched from PubMed, Elsevier Science, Springer Link, Medline, and Cochrane Library database as of June 2018. 30511687 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Certain haplotype combinations, DRB1*07-DQβ1*03 (OR: 2.21; 95% CI:1.29-3.79, p<sub>c</sub> = 0.06, p =  0.00036) and DRβ1*07-DQβ1*05 (OR: 2.51, 95% CI: 1.34-4.71, p<sub>c</sub> = 0.07, p = 0.00039), had positive associations whereas DRβ1*14-DQβ1*03 (OR: 0.14, 95% CI: 0.061-0.36, p<sub>c</sub> = 2.34 × 10<sup>-5</sup>, p = 1.30 × 10<sup>-6</sup>) were found to have a significant negative association with SLE. 29439646 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE In conclusion, our observations showed that HLA-G 14bp ins allele represents a genetic contribution on early-onset SLE independent of DRB1. 27331404 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Classic HLA allele imputation analysis identified HLA-DRB1*1501 and HLA-DQB1*0602, each highly correlated with one another, as most strongly associated with SLE. 26663301 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE. 26919467 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE We detected 6 HLA-DRB1 alleles that were associated with SLE in Koreans. 26663868 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE We found an increase in risk of maternal SLE associated with exposure to children who inherited DRB1*04:01 from their father (OR 1.9; 95% CI, 1.1-3.2), among *04:01 allele-negative mothers. 27388144 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls). 26605347 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE A total of 25 case-control studies on the relationship between gene polymorphism of HLA-DRB l and SLE were performed and data were analyzed and processed using Review Manager 5.2 and Stata 11.0. 25546242 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Polymorphisms in several genes were associated with IL-6 levels (including IL10, TYK2, and CD40L in SLE and DRB1, NOD2, and CSF1 in RA) or with TNFα levels (including TNFSF4 and CSF2 in SLE and PTPN2, DRB1, and NOD2 in RA). 25652333 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 SusceptibilityMutation disease ORPHANET Our data suggest an association between MHC class I and class II (HLA-A*29, HLA-B*51, HLA-DRB1*15, and HLA-DQB1*06) and susceptibility to SLE in the Saudi population. 23793423 2014
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease BEFREE The 7 SNPs and 4 HLA-DRB1 alleles associated with SLE did not display strong associations with ANA positivity. 25186300 2014
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE CFH (P=8.41 × 10(-6)), HLA-DRA (P=4.91 × 10(-6)), HLA-DRB1 (P=9.46 × 10(-9)), PXK (P=3.62 × 10(-4)), BLK (P=9.32 × 10(-3)), and UBE2L3 (P=4.07 × 10(-3)) were identified as shared genes between IgAN and SLE. 24458077 2014
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies. 24598797 2014
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Significantly different carrier frequencies of certain DRB1 alleles were found to be associated with SLE as follows: increased DRB1*15:01 (P = 5.48×10⁻¹⁰, corrected P (Pc) = 1.59×10⁻⁸, odds ratio [OR] 2.17, 95% confidence interval [CI] 1.69-2.79), decreased DRB1*13:02 (P = 7.17×10⁻⁵, Pc = 0.0020, OR 0.46, 95% CI 0.34-0.63) and decreased DRB1*14:03 (P = 0.0010, Pc = 0.0272, OR 0.34, 95% CI 0.18-0.63). 24498373 2014
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes. 23407388 2013
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 GeneticVariation disease GWASDB Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.700 Biomarker disease BEFREE Interestingly, HLA-DRB1*09:01 has been shown to be associated with multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus, suggesting that either HLA-DRB1*09:01 itself or other genes in tight linkage disequilibrium may play a role in a molecular pathway shared by various autoimmune diseases in Japanese and possibly in other Asian populations. 23180035 2013