TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
A defect in TCR-proximal signaling is a major characteristic of CD4 T cells in systemic lupus erythematosus; however, it is not fully known how defects in TCR signaling lead to lupus-like systemic autoimmunity characterized by germinal center development and autoantibody production against nuclear Ags.
|
31019063 |
2019 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exposure of normal T cells to SLE serum IgG, known to contain anti-CD3/TCR Abs, resulted in SAP downregulation.
|
27183584 |
2016 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
This activity was inhibited by anti-CD40L antibody, as well as anti-CD1d antibody, confirming a role for CD40L-CD40 and TCR-CD1d interactions in lupus iNKT-cell-mediated help.
|
25352488 |
2015 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study provides a new perspective for studying SLE with progression of disease in clonal level of TCR, which may provide a basis for studying the mechanism of the MRL/lpr autoreactive T cells response and tailor an individualized treatment targeting these T cells.
|
25335895 |
2015 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
TCR-αβ(+)CD3(+)CD4(-)CD8(-) "double negative" T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus (SLE) and lupus-prone mice.
|
24297179 |
2014 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ancestral Ala471 CD5 allele confers lymphocyte hyper-responsiveness to TCR/CD3 cross-linking and is associated with nephritis in SLE patients.
|
25402503 |
2014 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, engagement of SLAMF3 and SLAMF6 along with Ag-mediated CD3/TCR stimulation represents an important source of IL-17 production, and disruption of this interaction with decoy receptors or blocking Abs should mitigate disease expression in SLE and other autoimmune conditions.
|
22184727 |
2012 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
T cell receptor (TCR/CD3)-mediated stimulation of SLE T cells show increased protein tyrosine phosphorylation of cellular proteins with faster kinetics, heightened calcium flux response, and decreased IL-2 production.
|
22933064 |
2012 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
T cells from patients with systemic lupus erythematosus (SLE) are characterized by heightened TCR-initiated free intracytoplasmic calcium responses.
|
17237447 |
2007 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, we reported that in SLE T cells, the residual TCR zeta protein is predominantly derived from an alternatively spliced form that undergoes splice deletion of 562 nt (from 672 to 1233 bases) within the 3' untranslated region (UTR) of TCR zeta mRNA.
|
17114503 |
2006 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of these responsive genes in T cells in which the zeta and TCR/CD3 complexes were down-regulated may help to better understand the pathogenesis of systemic lupus erythematosus.
|
16393980 |
2006 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, multiple factors, including altered receptor structure, modulation of membrane clustering, lipid-raft distribution of signaling molecules, and defective signal silencing mechanisms, play a key role in delivering the increased TCR/CD3-mediated intracellular calcium response in SLE T cells.
|
15204087 |
2005 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review we discuss the unique features of the TCR zeta defects in SLE.
|
16227148 |
2005 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study identifies CaMKIV as being responsible for the increased expression of CREM and the decreased production of IL-2 in SLE T cells and demonstrates that anti-TCR/CD3 antibodies present in SLE sera can account for the increased expression of CREM and the suppression of IL-2 production.
|
15841182 |
2005 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
T cells isolated from patients with systemic lupus erythematosus (SLE) express low levels of CD3zeta-chain, a critical molecule involved in TCR-mediated signaling, but the involved mechanisms are not fully understood.
|
16116236 |
2005 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that there was plasticity or degeneracy of the TCR reactive with these lupus autoantigens in that two structurally dissimilar lupus autoantigenic peptides could stimulate a single TCR.
|
15004202 |
2004 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients with Sjögren's syndrome (SS) or systemic lupus erythematosus (SLE) were compared with normal controls with regard to TCR genotypes and serologic profiles.
|
14730616 |
2004 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Decreased number of T cells bearing TCR rearrangement excision circles (TREC) in active recent onset systemic lupus erythematosus.
|
15645744 |
2004 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, the lower stability of zetamRNA/as-3'UTR, which is predominant in SLE T cells, may be responsible for the reduced expression of the TCR/CD3 complex, including zeta protein, in SLE T cells.
|
12928398 |
2003 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results confirm the defective expression and altered tyrosine phosphorylation of TCR zeta in a large proportion of SLE patients, suggesting that it may play an important role in T cell dysfunction in SLE.
|
12100036 |
2002 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A vast majority of systemic lupus erythematosus (SLE) patients display decreased expression of TCR zeta-chain mRNA, a critical signaling molecule implicated in the selection of the TCR repertoire and in the prevention of autoimmunity.
|
11247639 |
2001 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, TCR/CD3 triggering of SLE T cells shows increased phosphorylation of downstream signaling intermediates and increased [Ca2+]i response, suggesting the presence of alternative signaling mechanisms.
|
11352243 |
2001 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Signaling molecules from the T cell receptor zeta/Fcepsilon receptor gamma (TCRzeta/FcRgamma) family play a critical role in the function of Fcgamma receptors and the TCR and are located on human chromosome 1, where lupus susceptibility genes are located.
|
10616006 |
1999 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mutations found in six of these patients corresponded to those of the third immunoreceptor tyrosine-based activation motif (ITAM) domain or the GTP/GDP binding site in TCR zetaThus, these mutations in TCR zeta mRNA could be responsible for the decreased expression of the TCR zeta protein in SLE T cells.
|
9802920 |
1998 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since exon 7 spans the GTP/GDP binding site and N-terminal tyrosine in the third ITAM domain of TCR zeta chain, the transcript lacking exon 7 may be responsible for altered signal transduction via TCR in these SLE patients.
|
9701029 |
1998 |