Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.060 Biomarker disease BEFREE Author Correction: Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. 31605099 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.060 Biomarker disease BEFREE Abbreviations: ALB: albumin; ARHGDIB: Rho GDP dissociation inhibitor beta; APOL1: apolipoprotein L1; ATG5: autophagy related 5; ATG7: autophagy related 7; ATG16L2: autophagy related 16 like 2; BECN1: beclin 1; CDKN1B: cyclin dependent kinase inhibitor 1B; CLEC16A, C-type lectin domain containing 16A; CYBB: cytochrome b-245 beta chain; DC: dendritic cell; DRAM1: DNA damage regulated autophagy modulator 1; eQTL: expression quantitative trait loci; GWAS: genome-wide association study; IFNA: interferon alpha; IRGM: immunity related GTPase M; LRRK2: leucine rich repeat kinase 2; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MTMR3: myotubularin related protein 3; LAP" LC3-associated phagocytosis; LN: lupus nephritis; NOD: non-obese diabetic; NPHS2: NPHS2, podocin; PBMC: peripheral blood mononuclear cell; RUBCN: rubicon autophagy regulator; SLE: systemic lupus erythematosus. 30755075 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.060 AlteredExpression disease BEFREE The glomerular number of 400 mg/kg treated mice was more than control group.Treatment with 400 mg/kg <i>D. candidum</i> reduced IL-6, IL-12, TNF-α and IFN-γcytokine levels as compared to control mice.<i>D. candidum</i> decreased NF-κb, TGF 'β1, Fas, FasL and increased IκB-α expressions in kidney tissue.There were 11 compounds in dry <i>D. candidum</i>, these compounds might make the curative effects of lupus nephritis. 28216896 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.060 Biomarker disease BEFREE Thus, although IFN-α is sufficient to induce nephritis acceleration, our data emphasize a critical role for IFN-independent signaling in TLR7-mediated lupus nephritis. 29884703 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.060 Biomarker disease BEFREE Complement inactivated serum, IgG-LN and IFN-α could induce podocyte autophagy in a time-dependent and dosage-dependent manner, and by reactive oxygen species production and mTORC1 inhibition, respectively. 30209031 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.060 AlteredExpression disease BEFREE Here we report that clinical and pathological lupus nephritis and serum anti-nuclear Ab levels are greatly attenuated in New Zealand Mixed (NZM) 2328 mice deficient in type I IFN receptors (IFNAR). 19812195 2009