In a subset of patients with samples available from the time of biopsy and subsequent clinical remission of LN, urinary levels of CD11b decreased with successful glucocorticoid treatment.
Genetic variants in the human <i>ITGAM</i> gene, which encodes for CD11b, are strongly associated with susceptibility to SLE, LN, and other complications of SLE.
Conclusion CD11brs1143679 appears to be associated with risk for SLE in the Han Chinese population, and may play an important role in the development of lupus nephritis.
Our meta-analyses confirm that the ITGAMrs1143679 polymorphism is associated with SLE susceptibility in different ethnic groups and demonstrate that the polymorphism is associated with LN in European.