| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | Since upregulation of glomerular Toll-like receptor 3 (TLR3) signaling reportedly plays a pivotal role in the pathogenesis of lupus nephritis (LN), we examined whether chloroquine affects TLR3-mediated expression of PAI-1 in cultured human glomerular endothelial cells (GECs). | 30341573 | 2019 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | In conclusion, the PAI-1 4G/5G gene polymorphism is not associated with susceptibility to SLE/lupus nephritis among overall populations, Asians and Caucasians. | 31002598 | 2019 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | 4G/5G plasminogen activator inhibitor-1 and -308 A/G tumor necrosis factor-α promoter gene polymorphisms in Argentinean lupus patients: focus on lupus nephritis. | 23143392 | 2014 | ||||
|
0.070 | Biomarker | disease | LHGDN | Likewise, the association between the FGB A allele and GMT was restricted to lupus nephritis patients homozygous for the PAI-1 4G allele. | 17469143 | 2007 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Likewise, the association between the FGB A allele and GMT was restricted to lupus nephritis patients homozygous for the PAI-1 4G allele. | 17469143 | 2007 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | The plasminogen activator inhibitor-1 (PAI-1) 4G/4G genotype influences the development of diabetic nephropathy and lupus nephritis. | 15481848 | 2004 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | PAI-1 genotype results were studied in relationship to the development and severity of lupus nephritis. | 11260416 | 2001 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | A dramatic increase in PAI-1 activity in plasma and in PAI-1 mRNA in the kidneys was observed in both models, and this increase appeared to correlate with fibrin deposition in the renal microvasculature and with the progression of lupus nephritis. | 9701458 | 1998 |