Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group BEFREE As only the son had the major clinical manifestations of ALPS-FAS, miR-21-3p should be investigated as playing a critical role in ALPS physiopathology, including the development of lymphoma. 27060458 2016
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group BEFREE Localized Store-Operated Calcium Influx Represses CD95-Dependent Apoptotic Effects of Rituximab in Non-Hodgkin B Lymphomas. 26202984 2015
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group BEFREE Our principal findings are that FAS mutations have a clinical penetrance of <60%, elevated serum vitamin B12 is a reliable and accurate biomarker of ALPS-FAS, and the major causes of morbidity and mortality in these patients are the overwhelming postsplenectomy sepsis and development of lymphoma. 24398331 2014
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 AlteredExpression group BEFREE In normal and lymphoma B cells, this correlated to increased CD95 membrane expression, enhanced DISC activity and engagement of the mitochondrial death pathway via Bid cleavage, although the latter occurred less efficiently in B-NHLr. 19751723 2009
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group BEFREE Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B cells to fas-induced apoptosis. 17277134 2007
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 GeneticVariation group LHGDN A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas. 17545588 2007
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group BEFREE Repression of TCL1 in GC B cells facilitates FAS-mediated apoptosis and prevents lymphoma formation. 17548807 2007
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 GeneticVariation group LHGDN Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations. 15160902 2004
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 GeneticVariation group BEFREE A loss of FAS (CD95) function has been proposed to constitute an important step in early mucosa-associated lymphoid tissue (MALT) lymphoma development and FAS mutations have been recognized in malignant lymphomas, in particular at extranodal sites. 14982861 2004
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 GeneticVariation group BEFREE Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations. 15160902 2004
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 GeneticVariation group BEFREE Somatic Fas mutations causing truncation of the Fas receptor were identified in two MALT-type lymphomas. 12950026 2003
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 AlteredExpression group BEFREE We demonstrate that CD95 mutations occur at low frequency in NHL tumors, however, surface expression of the CD95 protein varies with the subtype of lymphoma. 11697638 2002
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group BEFREE Accordingly, cell shrinkage did not induce apoptosis in CD95 receptor-negative lymphoma L1210 cells. 11598798 2001
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 GeneticVariation group BEFREE Fas (CD95, APO-1) mutations were found in autoimmune diseases and some lymphomas, suggesting impairment of Fas-mediated cell death signaling that may cause tumor development. 11454987 2001
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group BEFREE We conclude that the diagnosis of a FAS-FAS-L deficiency should be considered in children with an otherwise unexplained atypical lymphoproliferation and that a diagnosis of lymphoma in patients with functional FAS deficiency should be made with considerable reservation. 10403307 1999
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group BEFREE Recently, the Fas (CD95/APO-1)/Fas ligand system has been identified as a key regulator of apoptosis in some types of lymphoma cell lines. 9815617 1997
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group BEFREE Search for rearrangements and/or allelic loss of the fas/APO-1 gene in 101 human lymphomas. 7572793 1995
Entrez Id: 355
Gene Symbol: FAS
FAS
0.400 Biomarker group GENOMICS_ENGLAND