Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression group BEFREE Here we report up-regulation of COX-2and p53 protein expression in SLL and DLBCL indicating their interactive involvement in the pathogenesis of lymphoma. 31187468 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE MYD88/CD79B, DNMT3A, and TP53 were chosen as genes of interest, representing each of the following categories: lymphoma driver genes, CHIP-related genes, and genes shared between lymphoma and CHIP. 31436356 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation group BEFREE Mechanistically, the reactivation response was dependent on Cdkn2a/p19Arf, which is commonly silenced in p53 wild-type lymphomas, but became reexpressed upon late-stage p53 inactivation. 31611375 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE We identified 122 patients diagnosed as having large B-cell lymphoma (44, MYC-negative; 29, MYC-EC; 23, MYC rearrangement; 22, MYC and BCL2 rearrangements; 4, MYC, BCL2, and BCL6 rearrangements). p53 expression significantly correlated with DLBCL with abnormal MYC status (MYC-EC, MYC rearrangement, and MYC overexpression), but adverse p53 prognostic effect was only seen with MYC-rearranged lymphoma. 30496802 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation group BEFREE However, together they drive rapid onset lymphoma without mutational loss of p53. 31257681 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation group BEFREE Based on our recommendations, we systematically characterized all new cell lines that we generated by a standardized approach that included (1) determination of human origin, (2) exclusion of lymphoma, (3) DNA fingerprinting and histological comparisons to establish linkage to presumed tissue of origin, (4) examining thyroid differentiation by screening two to three thyroid markers, (5) examination of biological behavior (growth rate, tumorigenicity), and (6) presence of common thyroid cancer genetic changes (TP53, BRAF, PTEN, PIK3CA, RAS, TERT promoter, RET/PTC, PAX8/PPARγ, NF1, and EIF1AX). 29846633 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE TRRAP silencing attenuated p53 accumulation in lymphoma and colon cancer models, whereas TRRAP overexpression increased mutp53 levels, suggesting a role for TRRAP across cancer entities and p53 mutations. 29653964 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression group BEFREE In particular, patients with high TP53 expression (>50% positive lymphoma cells) had a shorter TTF and poor OS independent of both MIPI score and Ki-67 index. 29196411 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE Recombinant adenovirus p53 combined with radiotherapy improves efficacy and safety in the treatment of head and neck lymphoma. 30198865 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE Furthermore, the results suggest that the WW motif has dual functions that regulate p53 and inhibit <i>Myc</i>-driven lymphomas independent of p53. 29581299 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE Further examination of direct p53 target genes implicated in DNA repair showed that knockdown of Mlh1, Msh2, Rnf144b, Cav1 and Ddit4 accelerated MYC-driven lymphoma development to a similar extent as knockdown of p53. 29892060 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE Interestingly, experiments in mouse models have proven that conditional T-cell specific deletion of Cdkn1c gene may induce a differentiation block at the DN3 to DN4 transition, and that the loss of this gene in the absence of Tp53 led to aggressive thymic lymphomas. 29661169 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE The subsequent accumulation of genetic mutations and/or epigenetic modifications in driver genes, such as DDX3X and TP53, may lead to overt lymphoma and leukemia. 29896680 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation group BEFREE However, TP53 mutation in peripheral mature T and NK cell lymphomas has not been extensively investigated. 29885407 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression group BEFREE Patients with lymphoma showing concurrent P53 expression and MYC-R had a worse prognosis compared with patients with either P53 expression or MYC-R alone (P<0.0001). 27739436 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation group BEFREE Mutations and deletions of the tumor suppressor TP53 gene are the most frequent genetic alterations detected in human tumors, though they are rather less frequent in lymphomas. 28791403 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation group BEFREE TP53 mutations are independent predictors of survival in untreated patients with aggressive CD20+ lymphoma. 28614910 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE Immunophenotypic analysis showed that the lymphoma cells were positive for cyclin D1 (n=16/16), Myc (9/11), and P53 (n=9/9). 27776009 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression group BEFREE In mouse models, the Runx genes appear to act as conditional oncogenes, as ectopic expression is growth suppressive in normal cells but drives lymphoma development potently when combined with over-expressed Myc or loss of p53. 27869314 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation group BEFREE Analysis of other B cell markers revealed a lack of paired box 5 (PAX5) in CD19 positive lymphomas with mutant TP53 (50%), which was more frequent compared to tumors with wild-type TP53 (15%, p = 0.002). 28484276 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation group BEFREE We previously showed that the HSP90 inhibitor ganetespib potently suppresses T-lymphoma initiation and progression and extends overall survival (OS) in hotspot knockin mice expressing the p53 gain-of-function mutants R175H and R248Q (mutp53) by 30-59%. 28300840 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE Analysis of mRNA levels for p53 transcriptional targets showed that a subset of p53 targets in the p53-null lymphomas and HCT116 cells were activated despite the absence of functional p53. 28427210 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression group BEFREE Furthermore, a marked reduction of P53 expression levels were demonstrated in thymic lymphomas and spleens with a metastatic tumor. 28943948 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation group BEFREE Here we show that somatic heterozygous deletion of mouse chromosome 11B3, a 4-megabase region syntenic to human 17p13.1, produces a greater effect on lymphoma and leukaemia development than Trp53 deletion. 26982726 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker group BEFREE Notably, despite their continued growth and tumorigenic potential, Runx1null lymphoma cells displayed impaired proliferation and markedly increased sensitivity to DNA damage and dexamethasone-induced apoptosis, validating Runx1 function as a potential therapeutic target in Myc-driven lymphomas regardless of their p53 status. 27056890 2016