Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 AlteredExpression group BEFREE ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. 31690822 2020
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group RGD Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. 27895165 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group RGD A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. 28007901 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group GENOMICS_ENGLAND Germline Genetic Predisposition to Hematologic Malignancy. 28297620 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group BEFREE Although EμCyclinD1 is not sufficient to induce lymphomas, EμCyclinD1 accelerates the kinetics and increases the incidence of clonal lymphomas in ATM-deficient B-cells and skews the lymphomas toward pre-GC-derived small lymphocytic neoplasms, sharing morphological features of human MCL. 25676421 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group BEFREE In humans, ATM deficiency predisposes to B- and T-cell lymphomas, but in mice it leads only to thymic lymphomas. 24913718 2014
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group BEFREE Finally, we demonstrate that DNA-PKcs inhibitors are effective as single agents against ATM-defective lymphomas in vivo. 23761041 2013
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group BEFREE Overall, these data identify a novel molecular mechanism through which ATM kinase may regulate the immune system homeostasis and impair lymphoma development. 17932249 2008
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group BEFREE We hypothesize that ATM function is slightly attenuated by some variants, which could reduce double-stranded break repair capacity, contributing to the occurrence of translocations and subsequent lymphomas. 17640065 2007
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation group BEFREE The mutations in the ATM gene may be involved in the development of some subtypes of sporadic lymphomas and leukemias. 17516749 2007
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 AlteredExpression group BEFREE The methylation status of the ATM promoter CpG island was determined in 25 samples; ATM protein expression was assessed by Western blot in 9 lymphomas. 16631465 2006
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation group BEFREE Inherited biallelic mutations of the ATM (ataxia-telangiectasia mutated) gene cause ataxia-telangiectasia, a rare autosomal recessive disorder associated with a high incidence of childhood leukaemias and lymphomas, suggesting that ATM gene alterations may be involved in lymphomagenesis. 14628072 2004
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation group BEFREE ATM mutations have been reported in adult sporadic lymphoma and leukaemia. 14735203 2004
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation group BEFREE However, surveys of the ATM mutation status in lymphoma have been limited due to the large size (62 exons) and complex mutational spectrum of this gene. 12697903 2003
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation group BEFREE Germ-line mutations in the ATM gene cause ataxia-telangiectasia (A-T), a multisystem disorder associated with predisposition to lymphoma and acute leukemia. 12149228 2002
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group BEFREE The recurrent 11q22-23 deletions found in mantle cell lymphoma (MCL) suggest that ATM could be inactivated in these lymphomas. 11756177 2002
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation group BEFREE Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma. 12148890 2002
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 AlteredExpression group BEFREE The association between mutation of the ATM gene and a high incidence of lymphoid malignancy in patients with AT, together with the development of lymphoma in Atm deficient mice, supports the proposal that inactivation of the ATM gene may be of importance in the pathogenesis of sporadic lymphoid malignancy. 11429421 2001
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation group BEFREE A hemizygous ATM deletion was seen in 44% to 88% of the interphase cells in 15 cases (11.1%); four patients had an indolent lymphoma (follicular center cell lymphoma), and 11 patients had an aggressive lymphoma (five mantle-cell lymphomas [MCLs] and six diffuse large-cell lymphomas). 10893293 2000
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation group BEFREE We have found previously an overrepresentation (3.4%) of ATM mutations in a subset of 88 selected breast cancer patients with a family history of breast cancer, leukemia, and lymphoma. 9537233 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group BEFREE While ATM plays a major role in signaling the p53 response to DNA strand break damage, Atm-/- p53(-/-) mice develop lymphomas earlier than Atm-/- or p53(-/-) mice, indicating that mutations in these two genes lead to synergy in tumorigenesis. 9632822 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation group BEFREE The ATM gene deficient in ataxia-telangiectasia, a recessive multisystem disease associated with a high risk of lymphomas and leukemias, was found previously to be inactivated in a rare sporadic malignancy, T-cell prolymphocytic leukemia (T-PLL), which is often associated with cytogenetic aberrations of chromosome 14. 9622061 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GenomicAlterations group CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 CausalMutation group CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker group HPO