Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE By N-PCR, a total of 42 (51%) FL cases showed BCL-2 rearrangement: 28 (34%) for major breakpoint region (MBR) and 14 (17%) for minor cluster region (mcr). 14757440 2004
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease LHGDN We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci. 16194898 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Follicular lymphoma (FL) is an indolent, mature B-cell neoplasm classically characterised by the t(14;18)(q32;q21) with constitutive overexpression of the anti-apoptotic protein, BCL2. 31791624 2020
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE These data show that bcl-2 translocation is present in 57% of follicular lymphomas in Chinese patients, and support the notion that bcl-2 translocation is a consistent marker for follicular lymphomas irrespective of ethnic differences. 2223650 1990
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease LHGDN The low frequency of BCL-2/IgH translocation in healthy Chinese individuals of Han nationality located in Zhejiang area may be one of the reasons for the difference in the incidence of FL between China and Western countries. 16215945 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE In this patient's leukemic cells, the breakpoint of the t(14;18) translocation occurred in the major breakpoint-cluster region of the BCL2 gene and became linked to the JH4 joining-region gene segment of the immunoglobulin heavy-chain locus on the 14q+ chromosome as previously observed in follicular lymphoma. 3186743 1988
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Translocation t(14;18)(q32;q21) and/or BCL-2-IGH gene rearrangements were the genomic alterations most frequently observed: 50% of S-DLBCL and 30% of dn-DLBCL. 16519699 2006
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.600 GeneticVariation disease BEFREE EZH2 mutations were frequently associated with the presence of BCL2 rearrangement (BCL2-R) in both the FL (28% of BCL-R cases versus 0% of BCL2-WT cases, p<0.05) and GCB-DLBCL groups (33% of BCL2-R cases versus 4% of BCL2-WT cases, p<0.04), and across all lymphoma types excluding BL (27% of BCL2-R cases versus 3% of BCL2-WT cases, p<0.003). 22194861 2011
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Polymerase chain reaction (PCR) protocols have been developed to detect the t(14;18) translocation, which juxtaposes the bcl-2 proto-oncogene to the Ig heavy-chain (IgH) gene in 85% of follicular lymphomas and monoclonal rearrangements of the IgH gene in B-cell NHL that lack bcl-2 rearrangements. 8111048 1994
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Incidence and clinical significance of bcl-2/IgH rearrangements in follicular lymphoma. 12691144 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE The t(14;18)(q32;q21) associated with follicular lymphoma juxtaposes a portion of BCL-2 (18q21) and IGH(14q32); the result is bcl-2 overexpression. 12953811 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Detection and quantification of MBR/JH2 t(14;18) BCL-2 gene rearrangement in follicular lymphoma using a combined real-time polymerase chain reaction assay. 16704964 2006
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE The rest comprises a small part of low-grade FL without Bcl2 gene translocation and high-grade (grade 3a, 3b) FL. 15815725 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE FISH is better than BIOMED-2 PCR to detect IgH/BCL2 translocation in follicular lymphoma at diagnosis using paraffin-embedded tissue sections. 17964648 2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Follicular lymphoma is characterized by the presence of the t(14;18)(q32;q21) chromosomal translocation that juxtaposes the bcl-2 gene at 18q21 with the immunoglobulin heavy chain (IgH) locus at 14q32. 11950920 2002
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Molecular epidemiology of follicular lymphoma in Chinese: relationship with bcl-2/IgH translocation and bcl-6 397G/C polymorphism. 15875184 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci. 16194898 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE The chromosomal translocation t(14;18)(q32;q21), which involves the bcl-2 oncogene, occurs in most follicular lymphomas. 8209865 1994
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.600 GeneticVariation disease BEFREE The histone methyltransferase EZH2 is frequently mutated in germinal center-derived diffuse large B-cell lymphoma and follicular lymphoma. 24802772 2014
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Frequency of the Bcl-2/IgH rearrangement in normal individuals: implications for the monitoring of disease in patients with follicular lymphoma. 11208834 2001
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE The t(14;18)/IGH-BCL2 chromosomal translocation occurred frequently in gastrointestinal follicular lymphomas. 24048795 2011
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE To determine the relative importance of these mutations, we searched for their presence in DNA from the involved lymph nodes of 12 patients with t(14; 18) follicular lymphoma. bcl-2 genomic sequences were specifically amplified by the polymerase chain reaction technique and then directly sequenced. 2181381 1990
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.600 GeneticVariation disease BEFREE Early data from the tazemetostat trials indicate an acceptable safety profile and early signs of activity in diffuse large B-cell lymphoma and follicular lymphoma, including patients with EZH2 wild-type and mutant tumors. 29473431 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE In this retrospective study, we assess 157 patients with MYC/BCL2 DHL including 108 patients with de novo disease and 49 patients with a history of FL or rarely other types of low-grade B-cell lymphoma. 27203548 2016
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE The majority of follicular lymphomas have a rearrangement of the BCL2 gene, which is a pathogenetic factor in their development. 15474153 2004