Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.600 CausalMutation disease CGI
Entrez Id: 8915
Gene Symbol: BCL10
BCL10
0.420 CausalMutation disease CLINVAR
Entrez Id: 8915
Gene Symbol: BCL10
BCL10
0.420 CausalMutation disease CGI
Entrez Id: 8764
Gene Symbol: TNFRSF14
TNFRSF14
0.370 CausalMutation disease CGI
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE The bcl-2 oncogene is activated as a consequence of the t(14;18) chromosomal translocation in human follicular lymphomas. 1286168 1992
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE The Epstein-Barr virus (EBV) genome contains an open reading frame, BHRF1, that encodes a presumptive membrane protein with sequence similarity to the proto-oncogene bcl2, which is linked to human B-cell follicular lymphoma. 1312610 1992
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Detection of rearrangements of the BCL2 major breakpoint region in follicular lymphomas. Correlation of polymerase chain reaction results with Southern blot analysis. 1342952 1992
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE The translocation t(14;18)(q32;q21) occurs in 70% of follicular lymphomas and places the BCL2 proto-oncogene, normally located at 18q21, under the control of the immunoglobulin heavy chain (IgH) gene at 14q32. 1342952 1992
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE While all proliferating cells expressed both genes, BCL2 expression was increased two- to threefold in follicular lymphomas with t(14;18) and MYC expression was increased two- to four-fold in high-grade lymphomas with t(8;14). 1342969 1992
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE While all proliferating cells expressed both genes, BCL2 expression was increased two- to threefold in follicular lymphomas with t(14;18) and MYC expression was increased two- to four-fold in high-grade lymphomas with t(8;14). 1342969 1992
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE The BCL2 oncogene, which is located at band 18q21.3 and is activated by the t(14;18)(q32;q21) in follicular lymphoma, was not rearranged in this case. 1373320 1992
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE The bcl-2 gene is translocated into the Ig loci in about 80% of human follicular lymphomas and in 10% of B-type chronic lymphocytic leukemias (B-CLL), resulting in a high level of expression. 1375120 1992
Entrez Id: 931
Gene Symbol: MS4A1
MS4A1
0.100 AlteredExpression disease BEFREE In this study, we used flow cytometry to analyze the expression of CD20, a well-known B-cell-associated antigen, in lymphocytes from 42 cases of CLL and its tissue counterpart, small lymphocytic lymphoma (SLL), and compared the results with results obtained from the analysis of 21 follicular lymphomas, 20 hyperplastic reactive nodes, and 26 samples of normal peripheral blood. 1380203 1992
Entrez Id: 54474
Gene Symbol: KRT20
KRT20
0.100 AlteredExpression disease BEFREE In this study, we used flow cytometry to analyze the expression of CD20, a well-known B-cell-associated antigen, in lymphocytes from 42 cases of CLL and its tissue counterpart, small lymphocytic lymphoma (SLL), and compared the results with results obtained from the analysis of 21 follicular lymphomas, 20 hyperplastic reactive nodes, and 26 samples of normal peripheral blood. 1380203 1992
Entrez Id: 930
Gene Symbol: CD19
CD19
0.090 AlteredExpression disease BEFREE This antigen expression abnormality does not appear to be a universal phenomenon in CLL/SLL, since CD19, another pan-B antigen, was expressed in CLL/SLL at levels higher than those in follicular lymphomas and comparable to those in reactive lymph nodes. 1380203 1992
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Thus, additional steps must be involved in the clonal expansion of the FL tumor cell beyond the activation of bcl-2 as a consequence of the t(14;18) translocation. 1402658 1992
Entrez Id: 102724971
Gene Symbol: LOC102724971
LOC102724971
0.100 GeneticVariation disease BEFREE To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient. 1495966 1992
Entrez Id: 102723407
Gene Symbol: LOC102723407
LOC102723407
0.100 GeneticVariation disease BEFREE To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient. 1495966 1992
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.080 GeneticVariation disease BEFREE To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient. 1495966 1992
Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
0.050 GeneticVariation disease BEFREE To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient. 1495966 1992
Entrez Id: 390714
Gene Symbol: LOC390714
LOC390714
0.010 GeneticVariation disease BEFREE To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient. 1495966 1992
Entrez Id: 105379528
Gene Symbol: LOC105379528
LOC105379528
0.010 GeneticVariation disease BEFREE To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient. 1495966 1992
Entrez Id: 3903
Gene Symbol: LAIR1
LAIR1
0.010 GeneticVariation disease BEFREE To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient. 1495966 1992
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE In non-malignant tissues, the polymerase chain reaction was used to study the frequency of bcl-2/IgH rearrangements in reactive lymphoid tissue obtained from American and Japanese patients to find out whether geographic variation in the incidence of follicular lymphoma was caused by differences in sporadic occurrence of the t(14;18). 1497088 1992
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Further analysis of these tumors may provide insights into MYC deregulation and BCL2-independent FL. 1562738 1992