Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter's transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. 31631728 2020
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE Focusing on low-grade FL versus MZL, MEF2B was 100% sensitive and 95% specific for FL, which was similar to BCL6, but superior to LMO2 (sensitivity 87%, specificity 86%) and HGAL (sensitivity 97%, specificity 86%). 29309299 2018
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 GeneticVariation disease BEFREE Double-hit follicular lymphomas seemed to be a different disease from high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements and have an indolent clinical behavior similar to follicular lymphomas without MYC rearrangement. 28984304 2018
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 GeneticVariation disease BEFREE The most common scenario is transformation of follicular lymphoma to either diffuse large B-cell lymphoma or high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 translocations; however, other indolent subtypes such as marginal zone lymphoma, lymphoplasmacytic lymphoma, small lymphocytic lymphoma/chronic lymphocytic leukemia, or even nodular lymphocyte predominant Hodgkin lymphoma, can undergo similar histologic transformation. 30213394 2018
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 GeneticVariation disease BEFREE Fluorescent in situ hybridization detected IGH/BCL2 translocation in 1 FL, increased BCL6 copy number in another FL, BCL6 rearrangement, and increased copy number of MYC and MALT1 in the DLBCL with marginal zone lymphoma. 28038709 2017
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE Integrative genomics and functional studies of BCL6 in primary FL cells point toward a novel mechanism whereby BCL6 repression of <i>NOTCH2</i> drives the survival and growth of FL cells as well as GC B cells, which are the FL cell of origin.<i>Cancer Discov; 7(5); 506-21. 28232365 2017
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE To characterize PCFL and PCMZL more clearly and to define criteria helpful for the differential diagnosis, we compared expression of immunohistochemical markers [LIM-only transcription factor 2 (LMO2), human germinal centre-associated lymphoma (HGAL), stathmin 1 (STMN1), activation-induced cytidine deaminase (AID), myeloid cell nuclear differentiation antigen (MNDA)] and the presence of cytogenetic abnormalities described previously in nodal follicular lymphoma [B cell lymphoma 2 (BCL2) and BCL6 breaks, 1p36 chromosomal region deletion (del 1p36)] in a series of 48 cutaneous follicular and marginal zone lymphomas [cutaneous follicular lymphoma (CFL) and cutaneous marginal zone lymphoma (CMZL)]. 28594133 2017
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 GeneticVariation disease BEFREE We also found transcription factors (TF) whose binding may be disturbed by these mutations in FL: disruption of FOX TF family near the BCL6 promoter may result in reduced BCL6 expression, which then increases BCL2 expression over that caused by BCL2 gene translocation. 28765546 2017
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 AlteredExpression disease BEFREE Our findings evidence a positive correlation between SIRT1 and BCL6 expression increase in FL. 28324774 2017
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE Compared to CD10<sup>+</sup> GI-FL, CD10<sup>down</sup> GI-FL significantly involved the stomach or large intestine (P = 0.015), and additionally showed the downexpression of BCL6 (P < 0.001). 27513891 2016
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE We present here a unique case of follicular lymphoma (FL) with rearranged BCL2, BCL6, and BCL1 (also known as CCND1) genes. 25953460 2015
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE Numerous microRNAs were found to be differentially expressed between FL(BCL2+/BCL6+) and FL(BCL2-/BCL6+), as well as diffuse FL, when compared to typical cases of FL. 24778012 2014
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE Of the cases of FL (all CD10 and/or BCL-6 positive), 8 (80%) were positive for both HGAL and LMO2. 22914613 2013
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 GeneticVariation disease BEFREE The use of three distinct anti-bcl-2 antibodies together with CD10 expression data and FISH analysis for bcl-2 and bcl-6 rearrangements allowed subclassification of follicular lymphoma into four distinct subgroups: (i) CD10-positive/bcl-2-positive, (ii) CD10-positive/bcl-2-negative, (iii) CD10-negative/bcl-2-positive, and (iv) CD10-negative/bcl-2-negative.All cases were bcl-6-positive. 23509938 2013
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE All BCL6 translocations occurred in high-grade FL, and this suggests that FL carrying BCL6 translocation probably constitute a special biological subtype. 22968395 2012
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 FusionGene disease ORPHANET All BCL6 translocations occurred in high-grade FL, and this suggests that FL carrying BCL6 translocation probably constitute a special biological subtype. 22968395 2012
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE In our series, BCL-6 breaks were infrequent in BCL-2-negative follicular lymphoma. 21855110 2012
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 GeneticVariation disease BEFREE Translocations affecting BCL2 and BCL6 genes are rare in grade 3B follicular lymphomas (2/23, 9% and 4/23, 17%) when compared with grade 1 or 2 follicular lymphomas (22/25, 88%, P<0.001 and 0/25, P<0.05), FL/LCC (7/9, 78%, P<0.001 and 2/9, 22%), grade 3A follicular lymphomas (7/12, 58%, P<0.01 and 2/12, 17%), unclassified grade 3 follicular lymphomas (6/15, 40% and 2/15, 13%) and diffuse large B-cell lymphoma/follicular lymphoma grade 3B (2/16, 13% and 8/16, 50%, P<0.05). 21659362 2011
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE We studied the efficacy of 2 germinal center B-cell markers, HGAL and LMO2, in the separation of lymphomas derived from small B cells, particularly follicular lymphoma (FL) and marginal zone lymphoma occurring in nodal, extranodal, splenic, and bone marrow sites using immunohistochemical analysis for CD10, BCL6, BCL2, HGAL, and LMO2. 21502424 2011
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE BCL6-mediated suppression of BCL2 is lost in FL and DLBCL, where the 2 proteins are pathologically coexpressed, because of BCL2 chromosomal translocations and other mechanisms, including Miz1 deregulation and somatic mutations in the BCL2 promoter region. 19549844 2009
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 GeneticVariation disease BEFREE BCL6 rearrangements were found in all grades of follicular lymphoma but were most frequent in grade 3 t(14;18)-negative follicular lymphoma (60%). 19465899 2009
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease BEFREE BCL2- and BCL6-translocations correlate with particular phenotypes of follicular lymphomas. 20032416 2009
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 GeneticVariation disease BEFREE To test the association of SHM with transformation of follicular lymphoma (FL), we sequenced mutational hot spots in five proto-oncogenes (BCL6, PAX5, RHOH, MYC and PIM1) in 32 low-grade FL (lgFL) with follicular histology and 26 transformed FL (tFL) with diffuse large cell histology. 18180034 2008
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 Biomarker disease LHGDN BCL6 gene aberration, especially amplification/3q27 gain, indicates the presence of certain morphological and phenotypical findings in follicular lymphoma cases without IGH/BCL2 rearrangement. 18500267 2008
Entrez Id: 604
Gene Symbol: BCL6
BCL6
0.400 GeneticVariation disease BEFREE Our data confirm the presence of a relationship between histological grade and translocation status, suggesting that FLs carrying BCL6 translocations probably constitute a special biological subtype. 18203018 2008