Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Follicular lymphoma (FL) is an indolent, mature B-cell neoplasm classically characterised by the t(14;18)(q32;q21) with constitutive overexpression of the anti-apoptotic protein, BCL2. 31791624 2020
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE It is considered that BCL2 overexpression underscores the development of the majority of cases of FL and their transformation to more aggressive lymphoma [known as transformed FL (tFL)]. 31789408 2020
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Since 2000, we have investigated 67 consecutive patients with stage I/II follicular lymphoma (FL) for the presence of BCL2/IGH rearrangements by polymerase chain reaction (PCR), real time quantitative PCR (RQ-PCR) and digital droplet PCR (ddPCR). 31385309 2020
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter's transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. 31631728 2020
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.600 AlteredExpression disease BEFREE Several EZH2 inhibitors, which inhibit the methyltransferase activity of EZH2, have shown promise in treating sarcoma and follicular lymphoma in clinics. 31819273 2020
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Validating the association with HGBL-DH/TH- BCL2, 11 of 25 DHITsig-positive-transformed follicular lymphomas were classified as HGBL-DH/TH- BCL2 compared with zero of 50 in the DHITsig-negative group. 30523716 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Unraveling Tumor Heterogeneity in an Apparently Monolithic Disease: BCL2 and Other Players in the Genetic Landscape of Nodal Follicular Lymphoma. 30931307 2019
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.600 GeneticVariation disease BEFREE Follicular lymphoma (FL) is the most common indolent B-cell non-Hodgkin lymphoma (NHL) with genetic alterations of BCL-2, KMT2B, and KMT6. 30693983 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE This paper describes how we discovered the juxtaposition of the MYC gene to the human immunoglobulin loci and how that finding was extended to characterize molecularly the t(14;18) chromosome translocation of follicular lymphoma and to clone the BCL2 gene. 28653191 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE These include B-lymphocyte proliferation and sustained clonal expansion by HCV-envelope protein stimulation of B-cell receptors, and prolonged HCV-infected B-cell growth by overexpression of an anti-apoptotic BCL-2 oncogene caused by the increased frequency of t(14;18) chromosomal translocations in follicular lymphomas. 31092372 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Thus, either DLBCL or FL can give rise to aggressive double-hit lymphomas (DHL) with concurrent activation of MYC and BCL2. 30874346 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE Follicular lymphoma (FL) is the most common indolent B-cell non-Hodgkin lymphoma (NHL) with genetic alterations of BCL-2, KMT2B, and KMT6. 30693983 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE We showed that DLBCL with MYC/BCL2-DH, and those with BCL2 translocation, harbour the characteristic mutation signatures that are associated with follicular lymphoma and its high-grade transformation. 31844144 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Moreover, we tested its ability to discriminate follicular lymphomas by the tumour grade and the BCL2 protein expression. 30609603 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Molecular cytogenetics showed IGH/BCL2 fusion in the follicular lymphoma and amplification of IGH gene or trisomy/tetrasomy 14 in the PTCL. 29217426 2018
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.600 GeneticVariation disease BEFREE Early data from the tazemetostat trials indicate an acceptable safety profile and early signs of activity in diffuse large B-cell lymphoma and follicular lymphoma, including patients with EZH2 wild-type and mutant tumors. 29473431 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Follicular lymphoma (FL) is the most frequent indolent lymphoma in the Western world and is characterized in almost all cases by the t(14;18) translocation that results in overexpression of BCL2, an anti-apoptotic protein. 29974035 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE We analyzed the presence of the t(14;18)(q32;q21) as a surrogate marker of the malignant clone in cells of the FL microenvironment using combined fluorescence immunophenotyping and interphase cytogenetics targeting the BCL2 gene locus. 29720207 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE These results suggest a diverse portfolio of genetic alterations that may induce or regulate BCL2 expression or promote pathogenesis of t(14;18)-negative FL as well as a less specific but increased crosstalk with the microenvironment that may compensate for the lack of N-glycosylation. 28824170 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE The development of follicular lymphoma (FL) from a founder B cell with an upregulation of B-cell lymphoma 2 (BCL2), via the t(14;18) translocation, to a proliferating clone, poised to undergo further transformation to an aggressive lymphoma, illustrates the opportunistic Darwinian process of tumorigenesis. 29666116 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE New concepts in follicular lymphoma biology: From BCL2 to epigenetic regulators and non-coding RNAs. 30360879 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Histopathological examination revealed FL of grade 1-2 with a follicular pattern and with strong expression of germinal center markers and B-cell lymphoma 2 (BCL2). 29963140 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE FISH analysis confirmed the presence of IgH/BCL2 rearrangement in both the low grade follicular lymphoma (FL) and transformed Langerhans cells sarcoma (LCS) samples, demonstrating a clonal relationship. 30322385 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE B-cell lymphoma 2 (BCL-2) was discovered at the breakpoint of the t(14;18) in follicular lymphoma >30 years ago. 30037885 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 GeneticVariation disease BEFREE The most common scenario is transformation of follicular lymphoma to either diffuse large B-cell lymphoma or high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 translocations; however, other indolent subtypes such as marginal zone lymphoma, lymphoplasmacytic lymphoma, small lymphocytic lymphoma/chronic lymphocytic leukemia, or even nodular lymphocyte predominant Hodgkin lymphoma, can undergo similar histologic transformation. 30213394 2018