Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8879
Gene Symbol: SGPL1
SGPL1
0.410 Biomarker disease GENOMICS_ENGLAND Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. 28165343 2017
Entrez Id: 8879
Gene Symbol: SGPL1
SGPL1
0.410 GeneticVariation disease BEFREE Our analysis showed that all S1PL-deficient genetic models in this study displayed lymphopenia, with sequestration of mature T cells in the thymus and lymph nodes. 19119317 2009
Entrez Id: 8879
Gene Symbol: SGPL1
SGPL1
0.410 Biomarker disease HPO
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE Interleukin-7 (IL7) plays a nonredundant role in T cell survival and homeostasis, which is illustrated in the severe T cell lymphopenia of IL7-deficient mice, or demonstrated in animals or humans that lack expression of either the IL7Rα or γ <sub>c</sub> chain, the two subunits that constitute the functional IL7 receptor. 31137085 2019
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE While IL-7 deficiency results in lymphopenia, overexpression of IL-7 can cause neoplasia in experimental models. 30373315 2018
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE Primary aims were to determine the safety of CYT107 in sepsis and its ability to reverse lymphopenia. 29515037 2018
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE Taken together, we demonstrated different perioperative dynamics of interleukin-7, which may contribute to favourable outcomes following robotic colorectal surgery including lower incidence of surgical site infections, milder surgery-induced lymphopenia, and beneficial interferon-γ dynamics. 29904108 2018
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE Conversely, increased IL-7 and IL-15 can expand memory T cells, including pathogenic tissue-resident memory T cells, as seen in lymphopenia and certain chronic-inflammatory disorders and malignancies. 29664568 2018
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE Thus, off-target inhibitory effects of IM on IL-7 and STAT5-p explain how T cell lymphopenia occurs in patients treated with IM. 28387753 2017
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7. 27421731 2017
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE Whether IL-7 and IL-15 are insufficient in patients with severe lymphopenia during severe sepsis warrants further investigations. 25692255 2015
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 AlteredExpression disease BEFREE Elevated serum interleukin 7 (IL-7) levels are observed in lymphopenic conditions, including idiopathic CD4 lymphopenia (ICL), which is characterized by CD4 lymphopenia in the absence of human immunodeficiency virus infection or other known immunodeficiency. 22454463 2012
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE The aberrant T-cell expansions associated with the pathogenesis of CIN result in increased proliferation/apoptosis and possibly exhaustion of peripheral blood T cells which, in association with the inadequate compensatory thymic export of new TREC expressing T cells partially because of IL-7 deficiency, may contribute to lymphopenia in CIN. 22092365 2012
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE Elevated IL-7 availability does not account for T cell proliferation in moderate lymphopenia. 21239710 2011
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease CTD_human An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis. 17151827 2007
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease LHGDN In addition, IL-7 plays a major role in the expansion of mature T-cells that occurs during lymphopenia and therapeutic IL-7 can enhance both quantitative and functional immune recovery following T-cell depletion. 16923550 2006
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE IL-7 deficiency has now been found in patients with rheumatoid arthritis, a finding that relates not only to the T-lymphocyte status in this disease but also to the ability of patients with rheumatoid arthritis to recover from therapy-induced lymphopenia. 15642153 2005
Entrez Id: 3574
Gene Symbol: IL7
IL7
0.400 Biomarker disease BEFREE Although there is increasing interest in the use of IL-7 for the treatment of lymphopenia caused by the HIV type 1, evidence that IL-7 may accelerate HIV replication has raised concerns regarding its use in this setting. 12847229 2003
Entrez Id: 3239
Gene Symbol: HOXD13
HOXD13
0.300 Biomarker disease CTD_human Analysis of hematopathology and alteration of JAK1/STAT3/STAT5 signaling axis in experimental myelodysplastic syndrome. 27725143 2016
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.300 Biomarker disease CTD_human Analysis of hematopathology and alteration of JAK1/STAT3/STAT5 signaling axis in experimental myelodysplastic syndrome. 27725143 2016
Entrez Id: 10533
Gene Symbol: ATG7
ATG7
0.300 Biomarker disease CTD_human Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia. 26568842 2015
Entrez Id: 9474
Gene Symbol: ATG5
ATG5
0.300 Biomarker disease CTD_human Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia. 26568842 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.300 Biomarker disease CTD_human A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer. 1884014 1991
Entrez Id: 55340
Gene Symbol: GIMAP5
GIMAP5
0.260 GeneticVariation disease BEFREE Finally, we show that a human patient with a GIMAP5 loss-of-function mutation has lymphopenia and impaired T cell proliferation in vitro that can be rescued with GSK3 inhibitors. 29382851 2018
Entrez Id: 55340
Gene Symbol: GIMAP5
GIMAP5
0.260 Biomarker disease BEFREE GIMAP5 has a key role in BB-DR rat and NOD mouse lymphopenia. 25964488 2015